Black pepper ( Piper nigrum) fruit-based gold nanoparticles (BP-AuNPs): Synthesis, characterization, biological activities, and catalytic applications – A green approach

Abstract As compared to conventional techniques, currently nanotechnology has gained significant attention of scientists for the development of plant-based natural nanoparticles (NPs) due to their safety, effectiveness, and environment friendly nature. The current study was aimed for development, ch...

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Bibliographic Details
Published in:Green Processing and Synthesis
Main Authors: Bawazeer, Sami, Khan, Ibrahim, Rauf, Abdur, Aljohani, Abdullah S. M., Alhumaydhi, Fahad A., Khalil, Anees Ahmed, Qureshi, Muhammad Nasimullah, Ahmad, Laiba, Khan, Shahid Ali
Format: Article in Journal/Newspaper
Language:English
Published: Walter de Gruyter GmbH 2022
Subjects:
Carbonic acid
Online Access:http://dx.doi.org/10.1515/gps-2022-0002
https://www.degruyter.com/document/doi/10.1515/gps-2022-0002/xml
https://www.degruyter.com/document/doi/10.1515/gps-2022-0002/pdf
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Summary:Abstract As compared to conventional techniques, currently nanotechnology has gained significant attention of scientists for the development of plant-based natural nanoparticles (NPs) due to their safety, effectiveness, and environment friendly nature. The current study was aimed for development, characterization (energy-dispersive X-ray, ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, and scanning electron microscopy), and evaluation of the biological efficiency of black pepper (BP; Piper nigrum ) fruit-based gold NPs (BP-AuNPs) through different in vitro and in vivo assays. BP extract revealed maximum antibacterial and antifungal potential against Escherichia coli (24 mm) and Aspergillus flavus (47 mm), respectively. However, BP-AuNPs (200 µg·mL −1 ) inhibited the urease, xanthine oxidase, and carbonic acid-II activities with a percent inhibition of 83.11%, 91.28%, and 86.87%, respectively. Further, the anti-inflammatory effect of BP extract at the dose of 100 mg·kg −1 was 72.66%, whereas for BP-AuNPs it was noticed to be 91.93% at the dose of 10 mg·kg −1 . Similarly, the extract of BP and prepared AuNPs demonstrated significant ( p < 0.01) sedative effect at all tested doses. The BP-AuNPs catalytically reduced methyl orange dye. Results suggest that BP-AuNPs possess significant biological activities, and further studies must be conducted to identify the probable mechanism of action associated with these activities.

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