Metabolism of Single and Combined Doses of 14 C-Aldrin and 3 H- p , p ′-DDT by Atlantic Salmon ( Salmo salar ) Fry
Atlantic salmon (Salmo salar) fry were injected intramuscularly with 3 H-p,p′-DDT and 14 C-aldrin either alone or as a mixture at concentrations similar to those found in "naturally" contaminated fish; their rates of metabolism and clearance were then compared 3 H-p,p′-DDT was cleared slow...
| Published in: | Journal of the Fisheries Research Board of Canada |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Canadian Science Publishing
1976
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1139/f76-256 http://www.nrcresearchpress.com/doi/pdf/10.1139/f76-256 |
| Summary: | Atlantic salmon (Salmo salar) fry were injected intramuscularly with 3 H-p,p′-DDT and 14 C-aldrin either alone or as a mixture at concentrations similar to those found in "naturally" contaminated fish; their rates of metabolism and clearance were then compared 3 H-p,p′-DDT was cleared slowly from the fish: approximately 60% of the injected material remained 8 wk after injection. 14 C-aldrin was cleared much more rapidly, only 55% of the injected material remaining in the fish 1 day after injection and less than 10% remaining at the end of the experiment 3 H-p,p′-DDT was dehydrochlorinated to p,p′-DDE; assuming an exponential rate of conversion, its half-life was 60 days. In contrast, 50% of the aldrin residues in the fish were epoxidized to dieldrin within 2 days. No interactions between the insecticides were observed although aldrin apparently induced a slight increase in the fraction of total body weight accounted for by liver. |
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