Isolation of iqalisetins A and B from a Tolypocladium sp. isolated from marine sediment from Frobisher Bay in Canada’s arctic

• Published in: Canadian Journal of Chemistry
• Main Authors: Grunwald, Alyssa L., Berrué, Fabrice, Overy, David P., Kerr, Russell G.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Canadian Science Publishing 2016
• Subjects: Arctic; Nunavut; Frobisher Bay
• Online Access: http://dx.doi.org/10.1139/cjc-2015-0439; http://www.nrcresearchpress.com/doi/full-xml/10.1139/cjc-2015-0439; http://www.nrcresearchpress.com/doi/pdf/10.1139/cjc-2015-0439

Two new decalin-tetramic acid compounds, iqalisetin A (1) and iqalisetin B (2), were identified from a Tolypocladium sp. isolated from a marine sediment sample collected from Frobisher Bay, Nunavut, in Canada’s arctic. The structures of the new compounds were elucidated by NMR experiments. The relative stereochemistry of the decalin skeleton was determined by NOESY experiments and confirmed that 1 and 2 contained a trans-decalin ring system. The absolute stereochemistry of the tetramic acid was determined using Marfey’s method. Compounds 1 and 2 did not exhibit any significant antimicrobial or cytotoxic activity.