Isolation of iqalisetins A and B from a Tolypocladium sp. isolated from marine sediment from Frobisher Bay in Canada’s arctic

Two new decalin-tetramic acid compounds, iqalisetin A (1) and iqalisetin B (2), were identified from a Tolypocladium sp. isolated from a marine sediment sample collected from Frobisher Bay, Nunavut, in Canada’s arctic. The structures of the new compounds were elucidated by NMR experiments. The relat...

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Bibliographic Details
Published in:Canadian Journal of Chemistry
Main Authors: Grunwald, Alyssa L., Berrué, Fabrice, Overy, David P., Kerr, Russell G.
Format: Article in Journal/Newspaper
Language:English
Published: Canadian Science Publishing 2016
Subjects:
Organic Chemistry
General Chemistry
Catalysis
Arctic
Nunavut
Frobisher Bay
Online Access:http://dx.doi.org/10.1139/cjc-2015-0439
http://www.nrcresearchpress.com/doi/full-xml/10.1139/cjc-2015-0439
http://www.nrcresearchpress.com/doi/pdf/10.1139/cjc-2015-0439
Description
Summary:Two new decalin-tetramic acid compounds, iqalisetin A (1) and iqalisetin B (2), were identified from a Tolypocladium sp. isolated from a marine sediment sample collected from Frobisher Bay, Nunavut, in Canada’s arctic. The structures of the new compounds were elucidated by NMR experiments. The relative stereochemistry of the decalin skeleton was determined by NOESY experiments and confirmed that 1 and 2 contained a trans-decalin ring system. The absolute stereochemistry of the tetramic acid was determined using Marfey’s method. Compounds 1 and 2 did not exhibit any significant antimicrobial or cytotoxic activity.

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