Seroprevalence of Sindbis virus and associated risk factors in northern Sweden
SUMMARY Mosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were...
| Published in: | Epidemiology and Infection |
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| Main Authors: | , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Cambridge University Press (CUP)
2013
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1017/s0950268813002239 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0950268813002239 |
| Summary: | SUMMARY Mosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive ( P = 0·047) and it was more common in subjects with a lower educational level ( P = 0·013) and living in small, rural communities ( P < 0·001). Seropositivity was associated with higher waist circumference ( P = 0·1), elevated diastolic blood pressure ( P = 0·037), and history of a previous stroke ( P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4–13·0, P = 0·011). |
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