Effects of aging on axon terminals in the dentate molecular layer
Normal aging results in a pronounced spatial memory deficit associated with a rapid decay of long-term potentiation at the synapses between the perforant path and spines in the medial and distal thirds of the dentate molecular layer (DML), suggesting the alteration of synaptic transmission in the de...
| Published in: | Proceedings, annual meeting, Electron Microscopy Society of America |
|---|---|
| Main Authors: | , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Cambridge University Press (CUP)
1987
|
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1017/s0424820100128924 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0424820100128924 |
| Summary: | Normal aging results in a pronounced spatial memory deficit associated with a rapid decay of long-term potentiation at the synapses between the perforant path and spines in the medial and distal thirds of the dentate molecular layer (DML), suggesting the alteration of synaptic transmission in the dentate fascia. While the number of dentate granule cells remains unchanged, and there are no obvious pathological changes in these cells associated with increasing age, the density of their axospinous contacts has been shown to decrease. There are indications that the presynaptic element is affected by senescence before the postsynaptic element, yet little attention has been given to the fine structure of the remaining axon terminals. Therefore, we studied the axon terminals of the perforant path in the DML across three age groups. 5 Male rats (Fischer 344) of each age group (3, 24 and 30 months), were perfused through the aorta. |
|---|