Sodium orthovanadate, a powerful vasoconstrictor in the gills of the common eel, Anguilla anguilla
Sodium orthovanadate added internally is a powerful vasoconstrictor in perfused, irrigated gills of Anguilla anguilla . The anion is active at concentrations as low as 10 -7 M and its action is antagonized by β-adrenergic vasodilators such as adrenaline and isoprenaline. These effects are discussed...
| Published in: | Journal of the Marine Biological Association of the United Kingdom |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Cambridge University Press (CUP)
1979
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1017/s0025315400042740 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0025315400042740 |
| Summary: | Sodium orthovanadate added internally is a powerful vasoconstrictor in perfused, irrigated gills of Anguilla anguilla . The anion is active at concentrations as low as 10 -7 M and its action is antagonized by β-adrenergic vasodilators such as adrenaline and isoprenaline. These effects are discussed in terms of the known mode of action of vanadate as an inhibitor of (Na + + K + )-dependent ATPase. The biological and pharmacological effects of naturally occurring vanadate are assessed. |
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