Endogenous biosynthesis of n-3 long-chain PUFA in Atlantic salmon

Abstract A more efficient utilisation of marine-derived sources of dietary n -3 long-chain PUFA ( n -3 LC PUFA) in cultured Atlantic salmon ( Salmo salar L.) could be achieved by nutritional strategies that maximise endogenous n -3 LC PUFA synthesis. The objective of the present study was to quantif...

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Bibliographic Details
Published in:British Journal of Nutrition
Main Authors: Mock, Thomas S., Francis, David S., Jago, Matthew K., Glencross, Brett D., Smullen, Richard P., Turchini, Giovanni M.
Format: Article in Journal/Newspaper
Language:English
Published: Cambridge University Press (CUP) 2019
Subjects:
Atlantic salmon
Salmo salar
Online Access:http://dx.doi.org/10.1017/s0007114519000473
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114519000473
Description
Summary:Abstract A more efficient utilisation of marine-derived sources of dietary n -3 long-chain PUFA ( n -3 LC PUFA) in cultured Atlantic salmon ( Salmo salar L.) could be achieved by nutritional strategies that maximise endogenous n -3 LC PUFA synthesis. The objective of the present study was to quantify the extent of n -3 LC PUFA biosynthesis and the resultant effect on fillet nutritional quality in large fish. Four diets were manufactured, providing altered levels of dietary n -3 substrate, namely, 18 : 3 n -3, and end products, namely, 20 : 5 n -3 and 22 : 6 n -3. After 283 d of feeding, fish grew in excess of 3000 g and no differences in growth performance or biometrical parameters were recorded. An analysis of fatty acid composition and in vivo metabolism revealed that endogenous production of n -3 LC PUFA in fish fed a diet containing no added fish oil resulted in fillet levels of n -3 LC PUFA comparable with fish fed a diet with added fish oil. However, this result was not consistent among all treatments. Another major finding of this study was the presence of abundant dietary n -3 substrate, with the addition of dietary n -3 end product (i.e. fish oil) served to increase final fillet levels of n -3 LC PUFA. Specifically, preferential β -oxidation of dietary C 18 n -3 PUFA resulted in conservation of n -3 LC PUFA from catabolism. Ultimately, this study highlights the potential for endogenous synthesis of n -3 LC PUFA to, partially, support a substantial reduction in the amount of dietary fish oil in diets for Atlantic salmon reared in seawater.

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