STUDIES ON THE PRESSOR SUBSTANCES OF THE CAUDAL NEUROSECRETORY SYSTEM OF TELEOST FISH: BIOASSAY AND FRACTIONATION

SUMMARY A method for the bioassay of the pressor substances in extracts of the urophyses of the teleost fish, Mugil auratus and Anguilla anguilla , is described. Ultracentrifugation, chromatography on Sephadex gel and treatment with trypsin and papain showed that the pressor principles are polypepti...

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Bibliographic Details
Published in:Journal of Endocrinology
Main Authors: CHAN, D. K. O., JONES, I. CHESTER, PONNIAH, S.
Format: Article in Journal/Newspaper
Language:unknown
Published: Bioscientifica 1969
Subjects:
Endocrinology
Endocrinology, Diabetes and Metabolism
Anguilla anguilla
Online Access:http://dx.doi.org/10.1677/joe.0.0450151
https://joe.bioscientifica.com/view/journals/joe/45/2/joe_45_2_001.xml
https://joe.bioscientifica.com/downloadpdf/journals/joe/45/2/joe_45_2_001.xml
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Summary:SUMMARY A method for the bioassay of the pressor substances in extracts of the urophyses of the teleost fish, Mugil auratus and Anguilla anguilla , is described. Ultracentrifugation, chromatography on Sephadex gel and treatment with trypsin and papain showed that the pressor principles are polypeptides. One fraction was protein-bound while two other fractions seem to be small molecules. Treatment with thioglycollate showed that disulphide bonds do not form an integral part of the active molecule. The possible function of these principles in the control of the caudal circulation is discussed.

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