The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar)
Seaward migration of Salmo salar is preceded by preparatory physiological adaptations (parr–smolt transformation) to allow for a switch from freshwater (FW) to seawater (SW), which also means a switch in ambient calcium from hypocalcic (<1 mM Ca 2+ ) to the plasma (~1.25 mM Ca 2+ ) and to strongl...
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crbioscientif:10.1677/joe-06-0198 2024-09-15T17:56:15+00:00 The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar) Lock, E J Ørnsrud, R Aksnes, L Spanings, F A T Waagbø, R Flik, G 2007 http://dx.doi.org/10.1677/joe-06-0198 https://joe.bioscientifica.com/view/journals/joe/193/3/1930459.xml https://joe.bioscientifica.com/downloadpdf/journals/joe/193/3/1930459.xml unknown Bioscientifica Journal of Endocrinology volume 193, issue 3, page 459-471 ISSN 0022-0795 1479-6805 journal-article 2007 crbioscientif https://doi.org/10.1677/joe-06-0198 2024-08-15T04:09:21Z Seaward migration of Salmo salar is preceded by preparatory physiological adaptations (parr–smolt transformation) to allow for a switch from freshwater (FW) to seawater (SW), which also means a switch in ambient calcium from hypocalcic (<1 mM Ca 2+ ) to the plasma (~1.25 mM Ca 2+ ) and to strongly hypercalcic (8–12 mM Ca 2+ ). Uptake, storage (skeleton, scales) and excretion of calcium need careful regulation. In fish, the vitamin D endocrine system plays a rather enigmatic role in calcium physiology. Here, we give direct evidence for calcitriol involvement in SW migration. We report the full sequence of the nuclear vitamin D receptor (sVDR0) and two alternatively spliced variants resulting from intron retention (sVDR1 and sVDR2). In FW parr, SW adapting smolts, and in SW adults, plasma concentrations of 25(OH)D 3 and 24,25(OH) 2 D 3 did not change significantly. Plasma calcitriol concentrations were lowest in FW parr, doubled during smoltification and remained elevated in SW adults. Increased calcitriol coincided with a twofold decrease in sVDR mRNA levels in gill, intestine, and kidney of FW smolts and SW adults, when compared with parr. Clearly, there was a negative feedback and dynamic response of the vitamin D endocrine system during parr–smolt transformation. The onset of these dynamic changes in FW parr warrants a further search for the endocrines that initiate these changes. We speculate that the vitamin D system plays a crucial role in calcium and phosphorus handling in Atlantic salmon. Article in Journal/Newspaper Atlantic salmon Salmo salar Bioscientifica Journal of Endocrinology 193 3 459 471 |
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Bioscientifica |
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Seaward migration of Salmo salar is preceded by preparatory physiological adaptations (parr–smolt transformation) to allow for a switch from freshwater (FW) to seawater (SW), which also means a switch in ambient calcium from hypocalcic (<1 mM Ca 2+ ) to the plasma (~1.25 mM Ca 2+ ) and to strongly hypercalcic (8–12 mM Ca 2+ ). Uptake, storage (skeleton, scales) and excretion of calcium need careful regulation. In fish, the vitamin D endocrine system plays a rather enigmatic role in calcium physiology. Here, we give direct evidence for calcitriol involvement in SW migration. We report the full sequence of the nuclear vitamin D receptor (sVDR0) and two alternatively spliced variants resulting from intron retention (sVDR1 and sVDR2). In FW parr, SW adapting smolts, and in SW adults, plasma concentrations of 25(OH)D 3 and 24,25(OH) 2 D 3 did not change significantly. Plasma calcitriol concentrations were lowest in FW parr, doubled during smoltification and remained elevated in SW adults. Increased calcitriol coincided with a twofold decrease in sVDR mRNA levels in gill, intestine, and kidney of FW smolts and SW adults, when compared with parr. Clearly, there was a negative feedback and dynamic response of the vitamin D endocrine system during parr–smolt transformation. The onset of these dynamic changes in FW parr warrants a further search for the endocrines that initiate these changes. We speculate that the vitamin D system plays a crucial role in calcium and phosphorus handling in Atlantic salmon. |
format |
Article in Journal/Newspaper |
author |
Lock, E J Ørnsrud, R Aksnes, L Spanings, F A T Waagbø, R Flik, G |
spellingShingle |
Lock, E J Ørnsrud, R Aksnes, L Spanings, F A T Waagbø, R Flik, G The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar) |
author_facet |
Lock, E J Ørnsrud, R Aksnes, L Spanings, F A T Waagbø, R Flik, G |
author_sort |
Lock, E J |
title |
The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar) |
title_short |
The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar) |
title_full |
The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar) |
title_fullStr |
The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar) |
title_full_unstemmed |
The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar) |
title_sort |
vitamin d receptor and its ligand 1α,25-dihydroxyvitamin d3 in atlantic salmon (salmo salar) |
publisher |
Bioscientifica |
publishDate |
2007 |
url |
http://dx.doi.org/10.1677/joe-06-0198 https://joe.bioscientifica.com/view/journals/joe/193/3/1930459.xml https://joe.bioscientifica.com/downloadpdf/journals/joe/193/3/1930459.xml |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Endocrinology volume 193, issue 3, page 459-471 ISSN 0022-0795 1479-6805 |
op_doi |
https://doi.org/10.1677/joe-06-0198 |
container_title |
Journal of Endocrinology |
container_volume |
193 |
container_issue |
3 |
container_start_page |
459 |
op_container_end_page |
471 |
_version_ |
1810432464966909952 |