Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets

Subtype H10 avian influenza A viruses (IAVs) have caused sporadic human infections and enzootic outbreaks among seals. In the fall of 2015, H10N7 viruses were recovered from gulls in Iceland, and genomic analyses showed that the viruses were genetically related with IAVs that caused outbreaks among...

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Bibliographic Details
Published in:Journal of Virology
Main Authors: Guan, Minhui, Hall, Jeffrey S., Zhang, Xiaojian, Dusek, Robert J., Olivier, Alicia K., Liu, Liyuan, Li, Lei, Krauss, Scott, Danner, Angela, Li, Tao, Rutvisuttinunt, Wiriya, Lin, Xiaoxu, Hallgrimsson, Gunnar T., Ragnarsdottir, Sunna B., Vignisson, Solvi R., TeSlaa, Josh, Nashold, Sean W., Jarman, Richard, Wan, Xiu-Feng
Other Authors: García-Sastre, Adolfo, HHS | National Institutes of Health
Format: Article in Journal/Newspaper
Language:English
Published: American Society for Microbiology 2019
Subjects:
Virology
Insect Science
Immunology
Microbiology
Iceland
Online Access:http://dx.doi.org/10.1128/jvi.00282-19
https://journals.asm.org/doi/pdf/10.1128/JVI.00282-19
Description
Summary:Subtype H10 avian influenza A viruses (IAVs) have caused sporadic human infections and enzootic outbreaks among seals. In the fall of 2015, H10N7 viruses were recovered from gulls in Iceland, and genomic analyses showed that the viruses were genetically related with IAVs that caused outbreaks among seals in Europe a year earlier. These gull-origin viruses showed high binding affinity to human-like glycan receptors. Transmission studies in ferrets demonstrated that the gull-origin IAV could infect ferrets, and that the virus could be transmitted between ferrets through direct contact and aerosol droplets. This study demonstrated that avian H10 IAV can infect mammals and be transmitted among them without adaptation. Thus, avian H10 IAV is a candidate for influenza pandemic preparedness and should be monitored in wildlife and at the animal-human interface.

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