Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites

TNT (2,4,6-trinitrotoluene) of explosive grade is highly toxic to marine forms that included fresh water unicellular green algae (Selenastrum capricornutum), tidepool copepods (Tigriopus californicus), and oyster larvae (Crassostrea gigas), and mutagenic to Salmonella typhimurium. On the basis of mu...

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Bibliographic Details
Published in:Applied and Environmental Microbiology
Main Authors: Won, W D, DiSalvo, L H, Ng, J
Format: Article in Journal/Newspaper
Language:English
Published: American Society for Microbiology 1976
Subjects:
Crassostrea gigas
Copepods
Online Access:http://dx.doi.org/10.1128/aem.31.4.576-580.1976
https://journals.asm.org/doi/pdf/10.1128/aem.31.4.576-580.1976
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Summary:TNT (2,4,6-trinitrotoluene) of explosive grade is highly toxic to marine forms that included fresh water unicellular green algae (Selenastrum capricornutum), tidepool copepods (Tigriopus californicus), and oyster larvae (Crassostrea gigas), and mutagenic to Salmonella typhimurium. On the basis of mutagenic assays carried out with a set of histidine-requiring strains of the bacterium, TNT was detected as a frameshift mutagen that significantly accelerates the reversion rate of a frameshift tester, TA-98. In contrast, the major microbial metabolites of TNT appeared to be nontoxic and nonmutagenic.

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