Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains
ABSTRACT We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin ( bont ) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identif...
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Online Access: | http://dx.doi.org/10.1128/aem.01573-14 https://journals.asm.org/doi/pdf/10.1128/AEM.01573-14 |
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crasmicro:10.1128/aem.01573-14 2024-09-15T18:11:01+00:00 Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains Weedmark, K. A. Lambert, D. L. Mabon, P. Hayden, K. L. Urfano, C. J. Leclair, D. Van Domselaar, G. Austin, J. W. Corbett, C. R. Nojiri, H. 2014 http://dx.doi.org/10.1128/aem.01573-14 https://journals.asm.org/doi/pdf/10.1128/AEM.01573-14 en eng American Society for Microbiology https://journals.asm.org/non-commercial-tdm-license Applied and Environmental Microbiology volume 80, issue 20, page 6334-6345 ISSN 0099-2240 1098-5336 journal-article 2014 crasmicro https://doi.org/10.1128/aem.01573-14 2024-07-01T04:07:36Z ABSTRACT We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin ( bont ) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identified two novel BoNT type E variants termed E10 and E11. Strains producing type E10 were found along the eastern coastlines of Hudson Bay and the shores of Ungava Bay, while strains producing type E11 were only found in the Koksoak River region of Nunavik. Strains producing BoNT/E3 were widespread throughout northern Canada, with the exception of the coast of eastern Hudson Bay. Article in Journal/Newspaper Hudson Bay Ungava Bay Nunavik ASM Journals (American Society for Microbiology) Applied and Environmental Microbiology 80 20 6334 6345 |
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Open Polar |
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ASM Journals (American Society for Microbiology) |
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crasmicro |
language |
English |
description |
ABSTRACT We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin ( bont ) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identified two novel BoNT type E variants termed E10 and E11. Strains producing type E10 were found along the eastern coastlines of Hudson Bay and the shores of Ungava Bay, while strains producing type E11 were only found in the Koksoak River region of Nunavik. Strains producing BoNT/E3 were widespread throughout northern Canada, with the exception of the coast of eastern Hudson Bay. |
author2 |
Nojiri, H. |
format |
Article in Journal/Newspaper |
author |
Weedmark, K. A. Lambert, D. L. Mabon, P. Hayden, K. L. Urfano, C. J. Leclair, D. Van Domselaar, G. Austin, J. W. Corbett, C. R. |
spellingShingle |
Weedmark, K. A. Lambert, D. L. Mabon, P. Hayden, K. L. Urfano, C. J. Leclair, D. Van Domselaar, G. Austin, J. W. Corbett, C. R. Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains |
author_facet |
Weedmark, K. A. Lambert, D. L. Mabon, P. Hayden, K. L. Urfano, C. J. Leclair, D. Van Domselaar, G. Austin, J. W. Corbett, C. R. |
author_sort |
Weedmark, K. A. |
title |
Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains |
title_short |
Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains |
title_full |
Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains |
title_fullStr |
Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains |
title_full_unstemmed |
Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains |
title_sort |
two novel toxin variants revealed by whole-genome sequencing of 175 clostridium botulinum type e strains |
publisher |
American Society for Microbiology |
publishDate |
2014 |
url |
http://dx.doi.org/10.1128/aem.01573-14 https://journals.asm.org/doi/pdf/10.1128/AEM.01573-14 |
genre |
Hudson Bay Ungava Bay Nunavik |
genre_facet |
Hudson Bay Ungava Bay Nunavik |
op_source |
Applied and Environmental Microbiology volume 80, issue 20, page 6334-6345 ISSN 0099-2240 1098-5336 |
op_rights |
https://journals.asm.org/non-commercial-tdm-license |
op_doi |
https://doi.org/10.1128/aem.01573-14 |
container_title |
Applied and Environmental Microbiology |
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80 |
container_issue |
20 |
container_start_page |
6334 |
op_container_end_page |
6345 |
_version_ |
1810448617837690880 |