Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains

ABSTRACT We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin ( bont ) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identif...

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Bibliographic Details
Published in:Applied and Environmental Microbiology
Main Authors: Weedmark, K. A., Lambert, D. L., Mabon, P., Hayden, K. L., Urfano, C. J., Leclair, D., Van Domselaar, G., Austin, J. W., Corbett, C. R.
Other Authors: Nojiri, H.
Format: Article in Journal/Newspaper
Language:English
Published: American Society for Microbiology 2014
Subjects:
Ecology
Applied Microbiology and Biotechnology
Food Science
Biotechnology
Hudson Bay
Nunavik
Canada
Hudson
Ungava Bay
Koksoak River
Online Access:http://dx.doi.org/10.1128/aem.01573-14
https://journals.asm.org/doi/pdf/10.1128/AEM.01573-14
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Summary:ABSTRACT We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin ( bont ) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identified two novel BoNT type E variants termed E10 and E11. Strains producing type E10 were found along the eastern coastlines of Hudson Bay and the shores of Ungava Bay, while strains producing type E11 were only found in the Koksoak River region of Nunavik. Strains producing BoNT/E3 were widespread throughout northern Canada, with the exception of the coast of eastern Hudson Bay.

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