Molecular Characterization of Ofloxacin-Resistant Mycobacterium tuberculosis Strains from Russia

ABSTRACT In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread...

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Bibliographic Details
Published in:Antimicrobial Agents and Chemotherapy
Main Authors: Mokrousov, Igor, Otten, Tatiana, Manicheva, Olga, Potapova, Yulia, Vishnevsky, Boris, Narvskaya, Olga, Rastogi, Nalin
Format: Article in Journal/Newspaper
Language:English
Published: American Society for Microbiology 2008
Subjects:
Northwest Russia
Online Access:http://dx.doi.org/10.1128/aac.00036-08
https://journals.asm.org/doi/pdf/10.1128/AAC.00036-08
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Summary:ABSTRACT In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread of fluoroquinolone-resistant tuberculosis in Russia may be due, at least partly, to the prevalence of the Beijing genotype in a local population of M. tuberculosis .

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