Regulation of breathing by CO 2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons

Receptor in the brain controls breathing Control of breathing in mammals depends primarily not on sensing oxygen, but rather on detecting concentrations of carbon dioxide in the blood. Failure of this system can cause potentially deadly sleep apnias. Taking a hint from insects, which use a heterotri...

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Bibliographic Details
Published in:Science
Main Authors: Kumar, Natasha N., Velic, Ana, Soliz, Jorge, Shi, Yingtang, Li, Keyong, Wang, Sheng, Weaver, Janelle L., Sen, Josh, Abbott, Stephen B. G., Lazarenko, Roman M., Ludwig, Marie-Gabrielle, Perez-Reyes, Edward, Mohebbi, Nilufar, Bettoni, Carla, Gassmann, Max, Suply, Thomas, Seuwen, Klaus, Guyenet, Patrice G., Wagner, Carsten A., Bayliss, Douglas A.
Other Authors: National Institutes of Health, Swiss National Science Foundation, National Health and Medical Research Council of Australia Early Career Fellowship
Format: Article in Journal/Newspaper
Language:English
Published: American Association for the Advancement of Science (AAAS) 2015
Subjects:
Carbonic acid
Online Access:http://dx.doi.org/10.1126/science.aaa0922
https://www.science.org/doi/pdf/10.1126/science.aaa0922
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Summary:Receptor in the brain controls breathing Control of breathing in mammals depends primarily not on sensing oxygen, but rather on detecting concentrations of carbon dioxide in the blood. Failure of this system can cause potentially deadly sleep apnias. Taking a hint from insects, which use a heterotrimeric guanine nucleotide–binding protein-coupled receptor (GPCR) to sense carbon dioxide, Kumar et al. demonstrate that the GPCR GPR4 is essential to control breathing in mice. GPR4 senses protons generated by the formation of carbonic acid in the blood and works with a pH-sensitive potassium channel called TASK-2 in a set of brain cells that control breathing. Science , this issue p. 1255

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