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Histological Study Of Protective Effects Of The Aqueous Extract Of Moringa Oleifera Seeds On Diclofenac-Induced Livers In Male Rats
by
Saleh
,
Nagham
,
Abdel-Hussein Kadhim AL–Essawi , Dalal
Published 2023
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1997( (8) and it is completely absorbed from the gastrointestinal tract
2012) (23),Many serious side effects of diclofenac include cardiovascular thrombosis
2014(32)
2020) (15). The reason for this can be attributed to the fact that diclofenac persists for more than 11 hours in the synovial fluid. Diclofenac drug inhibits synthesis of cyclooxygenase-1 and -2
2020) (20). It has also been used in the treatment of cardiovascular diseases
AL– Essawi and Aljamali ,2019) (16) Moringa oleifera plant is one of the important medicinal plants that has been used as a treatment for many diseases as a substitute for many drugs and medical medicines and this plant has been used since ancient times because it contains organic substances
Conclusion We can conclude from this study that the aqueous extract of Moringa oleifera seeds had a protective role in maintaining the histological structure of the liver in male white rats from the negative and harmful effects caused by the diclofenac drug within the therapeutic dose. Introduction Diclofenac drug is an anti-inflammatory drug that belongs to non-steroidal anti-inflammatory drugs
Key words: queous extract ,Moringa oleifera ,seeds
Moringa oleifera has entered medical laboratories as a healthy nutritional supplement to reduce malnutrition (Brar et al
amino acids
and antimicrobials (Abdel-Latif et al.,2022) (4). In this times
and migraine (Gokçimen et al.,2001) (21). Diclofenac absorption is rapid and complete when given orally and this drug is highly bound to plasma albumin )Davies and Anderson
and they can be used without a prescription to remove fever and relieve pain and used to treat mild to moderate pain
and thus reduces the incidence of infection With regard to the side effects of the digestive system
and when preventing the formation of this substance leads to a reduction in pain and inflammation
antihypertensives
antioxidants
as diclofenac inhibits the manufacture of cyclooxygenase 2 enzyme
burning eyes
but is likely to undergo first-pass metabolism with only 60% of the drug reaching the systemic circulation passing unnoticed) David et al.,2016) (7). The mechanism of action of diclofenac is summarized in its ability to inhibit the enzyme cyclooxygenase COX which helps in the formation of chemicals known as prostaglandins that cause pain and inflammation
carotenoids
compared to both indomethacin and aspirin
diclofenac
diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren
enzymes
exfoliative dermatitis and idiopathic use of many analgesics
eye infections
fever
flavonoids
glucosins
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