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12 species comprising Biochemistry Biological Sciences not elsewhere classified Evolutionary Biology bats (< bile acid metabolism bioinformatics study biological functions carnivores </ cell proliferation chiroptera </ codeml program decelerated rate detect evolutionary constraints div >< p evolutionary history functional relevance gene loss including lipid muridae </ natural selection rate paml package pcsk1 </ pcsk3 </ pcsk5 </ pcsk7 </ pcsk9 </ physiological functions playing critical roles positive selection