Isaac Holden
| birth_place = Hurlet, Renfrewshire, Scotland
| death_date =
| death_place = Oakworth, Yorkshire, England
| resting_place = Undercliffe Cemetery, Bradford
| nationality = British
| known_for =
| occupation = inventor and politician
}}
Sir Isaac Holden, 1st Baronet (7 May 1807 – 13 August 1897) was an inventor and manufacturer, who is known both for his work in developing the Square Motion wool-combing machine and as a Radical Liberal Member of Parliament.
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