Gary Ruvkun
Gary Bruce Ruvkun (born March 1952, Berkeley, California) is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston. Ruvkun discovered the mechanism by which ''lin-4'', the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, ''let-7'', and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Ruvkun also discovered many features of insulin-like signaling in the regulation of aging and metabolism. He was elected a Member of the American Philosophical Society in 2019. Provided by Wikipedia-
1by Alexandra Pontefract, Ting F. Zhu, Virginia K. Walker, Holli Hepburn, Clarissa Lui, Maria T. Zuber, Gary Ruvkun, Christopher E. CarrGet access
Published in Frontiers in Microbiology (2017)
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