Search Results - Open Polar - "secretase"

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The C99 domain of the amyloid precursor protein resides in the disordered membrane phase

by Capone, Ricardo, Tiwari, Ajit, Hadziselimovic, Arina, Peskova, Yelena, Hutchison, James M., Sanders, Charles R., Kenworthy, Anne K.
Published in Journal of Biological Chemistry (2021)
“... with the etiology of Alzheimer’s disease. The cleavage of APP by β-secretase to generate the transmembrane 99...”

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Point Mutations in Aβ Result in the Formation of Distinct Polymorphic Aggregates in the Presence of Lipid Bilayers

by Pifer, Phillip M., Yates, Elizabeth A., Legleiter, Justin
Published in PLoS ONE (2011)
“.... There are several mutations clustered around the central hydrophobic core of Aβ near the α-secretase cleavage site...”

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