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Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs).

by Jenna Shiels, Krystyna Cwiklinski, Raquel Alvarado, Karine Thivierge, Sophie Cotton, Bibiana Gonzales Santana, Joyce To, Sheila Donnelly, Clifford C Taggart, Sinead Weldon, John P Dalton
Published in PLOS Neglected Tropical Diseases (2020)

Surface Molecules Released by Trypanosoma cruzi Metacyclic Forms Downregulate Host Cell Invasion.

by Tatiana Mordente Clemente, Cristian Cortez, Antônio da Silva Novaes, Nobuko Yoshida
Published in PLOS Neglected Tropical Diseases (2016)

Metabolomics-Based Discovery of Small Molecule Biomarkers in Serum Associated with Dengue Virus Infections and Disease Outcomes.

by Natalia V Voge, Rushika Perera, Sebabrata Mahapatra, Lionel Gresh, Angel Balmaseda, María A Loroño-Pino, Amber S Hopf-Jannasch, John T Belisle, Eva Harris, Carol D Blair, Barry J Beaty
Published in PLOS Neglected Tropical Diseases (2016)

Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells.

by Eduardo de la Torre-Escudero, Jared Q Gerlach, Adam P S Bennett, Krystyna Cwiklinski, Heather L Jewhurst, Kathryn M Huson, Lokesh Joshi, Michelle Kilcoyne, Sandra O'Neill, John P Dalton, Mark W Robinson
Published in PLOS Neglected Tropical Diseases (2019)

Novel, meso-substituted cationic porphyrin molecule for photo-mediated larval control of the dengue vector Aedes aegypti.

by Leonardo Lucantoni, Michela Magaraggia, Giulio Lupidi, Robert Kossivi Ouedraogo, Olimpia Coppellotti, Fulvio Esposito, Clara Fabris, Giulio Jori, Annette Habluetzel
Published in PLoS Neglected Tropical Diseases (2011)

Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.

by Hideaki Shimizu, Akatsuki Saito, Junko Mikuni, Emi E Nakayama, Hiroo Koyama, Teruki Honma, Mikako Shirouzu, Shun-Ichi Sekine, Tatsuo Shioda
Published in PLOS Neglected Tropical Diseases (2019)

Identification of clinically approved small molecules that inhibit growth and affect transcript...

by Madison Elle Walsh, Eleanor Mary Naudzius, Savanah Jessica Diaz, Theodore William Wismar, Mikhail Martchenko Shilman, Danae Schulz
Published in PLOS Neglected Tropical Diseases (2020)

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.

by Roderick G Walker, Graeme Thomson, Kirk Malone, Matthew W Nowicki, Elaine Brown, David G Blake, Nicholas J Turner, Malcolm D Walkinshaw, Karen M Grant, Jeremy C Mottram
Published in PLoS Neglected Tropical Diseases (2011)

A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.

by Elizabeth R Sharlow, Todd A Lyda, Heidi C Dodson, Gabriela Mustata, Meredith T Morris, Stephanie S Leimgruber, Kuo-Hsiung Lee, Yoshiki Kashiwada, David Close, John S Lazo, James C Morris
Published in PLoS Neglected Tropical Diseases (2010)

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.

by Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi, Ons Zakraoui, Guillaume Bouvier, Khadija Essafi-Benkhadir, Josette Banroques, Nathan Desdouits, Hélène Munier-Lehmann, Mourad Barhoumi, N Kyle Tanner, Michael Nilges, Arnaud Blondel, Ikram Guizani
Published in PLOS Neglected Tropical Diseases (2018)

The B cell adaptor molecule Bam32 is critically important for optimal antibody response and resistance to Trypanosoma congolense infection in mice.

by Chukwunonso Onyilagha, Ping Jia, Nipun Jayachandran, Sen Hou, Ifeoma Okwor, Shiby Kuriakose, Aaron Marshall, Jude E Uzonna
Published in PLOS Neglected Tropical Diseases (2015)

Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species.

by Jéssica Cristina Dos Santos, Bas Heinhuis, Rodrigo Saar Gomes, Michelle S M A Damen, Fernando Real, Renato A Mortara, Samuel T Keating, Charles A Dinarello, Leo A B Joosten, Fátima Ribeiro-Dias
Published in PLOS Neglected Tropical Diseases (2017)

Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system.

by Yaneth Osorio, Bruno L Travi, Adam R Renslo, Alex G Peniche, Peter C Melby
Published in PLoS Neglected Tropical Diseases (2011)

Gp35/50 mucin molecules of Trypanosoma cruzi metacyclic forms that mediate host cell invasion interact with annexin A2.

by Thiago Souza Onofre, Leonardo Loch, João Paulo Ferreira Rodrigues, Silene Macedo, Nobuko Yoshida
Published in PLOS Neglected Tropical Diseases (2022)

Gp35/50 mucin molecules of Trypanosoma cruzi metacyclic forms that mediate host cell invasion interact with annexin A2

by Thiago Souza Onofre, Leonardo Loch, João Paulo Ferreira Rodrigues, Silene Macedo, Nobuko Yoshida
Published 2022

Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen.

by Elizabeth R Sharlow, David Close, Tongying Shun, Stephanie Leimgruber, Robyn Reed, Gabriela Mustata, Peter Wipf, Jacob Johnson, Michael O'Neil, Max Grögl, Alan J Magill, John S Lazo
Published in PLoS Neglected Tropical Diseases (2009)

Interaction of Signaling Lymphocytic Activation Molecule Family 1 (SLAMF1) receptor...

by Cristina Poveda, Alfonso Herreros-Cabello, Francisco Callejas-Hernández, Jesús Osuna-Pérez, María C Maza, Carlos Chillón-Marinas, Jossela Calderón, Konstantinos Stamatakis, Manuel Fresno, Núria Gironès
Published in PLOS Neglected Tropical Diseases (2020)

Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti...

by Karine Thivierge, Sophie Cotton, Deborah A Schaefer, Michael W Riggs, Joyce To, Maria E Lund, Mark W Robinson, John P Dalton, Sheila M Donnelly
Published in PLoS Neglected Tropical Diseases (2013)

Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads...

by Junhua Wang, Dominique A Vuitton, Norbert Müller, Andrew Hemphill, Markus Spiliotis, Oleg Blagosklonov, Denis Grandgirard, Stephen L Leib, Itay Shalev, Gary Levy, Xiaomei Lu, Renyong Lin, Hao Wen, Bruno Gottstein
Published in PLOS Neglected Tropical Diseases (2015)

Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense.

by Brett A Eyford, Laura Kaufman, Orly Salama-Alber, Bianca Loveless, Matthew E Pope, Robert D Burke, Enock Matovu, Martin J Boulanger, Terry W Pearson
Published in PLOS Neglected Tropical Diseases (2016)