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Advanced enzymology, expression profile and immune response of Clonorchis sinensis hexokinase show its application potential for prevention and control of clonorchiasis.

by Tingjin Chen, Jinyun Yu, Zeli Tang, Zhizhi Xie, Zhipeng Lin, Hengchang Sun, Shuo Wan, Xuerong Li, Yan Huang, Xinbing Yu, Jin Xu
Published in PLOS Neglected Tropical Diseases (2015)
“... molecular inhibitor regulated the enzymatic activity of rCsHK, and various allosteric systems were detected...”

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2

Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping.

by Mikael Engmark, Bruno Lomonte, José María Gutiérrez, Andreas H Laustsen, Federico De Masi, Mikael R Andersen, Ole Lund
Published in PLOS Neglected Tropical Diseases (2017)
“... for toxicity, but instead at other sites, of which some are known for allosteric inhibition or for interaction...”

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3

Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens.

by Gregory J Crowther, Michael L Booker, Min He, Ting Li, Sylvine Raverdy, Jacopo F Novelli, Panqing He, Natalie R G Dale, Amy M Fife, Robert H Barker, Martin L Kramer, Wesley C Van Voorhis, Clotilde K S Carlow, Ming-Wei Wang
Published in PLoS Neglected Tropical Diseases (2014)
“... that it may not be druggable, but another binding site might permit allosteric inhibition. As a comprehensive...”

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4

Caenorhabditis elegans muscle Cys-loop receptors as novel targets of terpenoids with potential anthelmintic activity.

by Guillermina Hernando, Ornella Turani, Cecilia Bouzat
Published in PLOS Neglected Tropical Diseases (2019)
“... decrease the frequency of opening events, probably by acting as negative allosteric modulators. The fact...”

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5

Relative neurotoxicity of ivermectin and moxidectin in Mdr1ab (-/-) mice and effects on mammalian GABA(A) channel activity.

by Cécile Ménez, Jean-François Sutra, Roger Prichard, Anne Lespine
Published in PLoS Neglected Tropical Diseases (2012)
“..., IVM and MOX were both allosteric activators of the GABA-induced response. The Hill coefficient...”

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6

Coevolution of the Ile1,016 and Cys1,534 Mutations in the Voltage Gated Sodium Channel Gene of Aedes aegypti in Mexico.

by Farah Z Vera-Maloof, Karla Saavedra-Rodriguez, Armando E Elizondo-Quiroga, Saul Lozano-Fuentes, William C Black Iv
Published in PLOS Neglected Tropical Diseases (2015)
“... resistance than mutants in either domain alone. Computer models predict an allosteric interaction between...”

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7

Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti.

by Mengli Chen, Yuzhe Du, Shaoying Wu, Yoshiko Nomura, Guonian Zhu, Boris S Zhorov, Ke Dong
Published in PLOS Neglected Tropical Diseases (2019)
“... of sodium channels suggest that T1520I allosterically deforms geometry of the pyrethroid receptor site PyR1...”

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