Search Results

Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.

by Juan Carlos Pizarro, Tanya Hills, Guillermo Senisterra, Amy K Wernimont, Claire Mackenzie, Neil R Norcross, Michael A J Ferguson, Paul G Wyatt, Ian H Gilbert, Raymond Hui
Published in PLoS Neglected Tropical Diseases (2013)

Taste, a new incentive to switch to (R)-praziquantel in schistosomiasis treatment.

by Thorsten Meyer, Harald Sekljic, Stefan Fuchs, Heiko Bothe, Dieter Schollmeyer, Christian Miculka
Published in PLoS Neglected Tropical Diseases (2009)

Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.

by Iain D Kerr, Peng Wu, Rachael Marion-Tsukamaki, Zachary B Mackey, Linda S Brinen
Published in PLoS Neglected Tropical Diseases (2010)

Structural basis for the high specificity of a Trypanosoma congolense immunoassay targeting glycosomal aldolase.

by Joar Pinto, Steven Odongo, Felicity Lee, Vaiva Gaspariunaite, Serge Muyldermans, Stefan Magez, Yann G-J Sterckx
Published in PLOS Neglected Tropical Diseases (2017)

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).

by Anjan Debnath, Claudia M Calvet, Gareth Jennings, Wenxu Zhou, Alexander Aksenov, Madeline R Luth, Ruben Abagyan, W David Nes, James H McKerrow, Larissa M Podust
Published in PLOS Neglected Tropical Diseases (2017)

A structural classification of the variant surface glycoproteins of the African trypanosome.

by Sara Đaković, Johan P Zeelen, Anastasia Gkeka, Monica Chandra, Monique van Straaten, Konstantina Foti, Janet Zhong, Evi P Vlachou, Francisco Aresta-Branco, Joseph P Verdi, F Nina Papavasiliou, C Erec Stebbins
Published in PLOS Neglected Tropical Diseases (2023)

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi inf...

by Claudia Magalhaes Calvet, Jun Yong Choi, Diane Thomas, Brian Suzuki, Ken Hirata, Sharon Lostracco-Johnson, Liliane Batista de Mesquita, Alanderson Nogueira, Marcelo Meuser-Batista, Tatiana Araujo Silva, Jair Lage Siqueira-Neto, William R Roush, Mirian Claudia de Souza Pereira, James H McKerrow, Larissa M Podust
Published in PLOS Neglected Tropical Diseases (2017)