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Charakterisierung eines Dimerisierungsmotivs in der Aβ-Region des Amyloid- Vorläuferproteins : Mechanismus der Aβ-Entstehung : Characterization of a dimerization motif within the Aβ region of the Amyloid precursor protein : mechanism of Aβ generation

by Münter, Lisa-Marie
Published 2008
“...). Processing of the amyloid precursor protein (APP) by β- and g-secretases leads to the generation of Aβ...”

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Familial Alzheimer’s disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vi...

by Tackenberg, Christian, Kulic, Luka, Nitsch, Roger M.
Published in PLOS Neglected Tropical Diseases (2020)
“... or in the gene encoding for the amyloid precursor protein (APP). Proteolytic cleavage of APP generates the β...”

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3

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains. ...

by Yang, Yang, Zhang, Wenjuan, Murzin, Alexey G, Schweighauser, Manuel, Huang, Melissa, Lövestam, Sofia, Peak-Chew, Sew Y, Saito, Takashi, Saido, Takaomi C, Macdonald, Jennifer, Lavenir, Isabelle, Ghetti, Bernardino, Graff, Caroline, Kumar, Amit, Nordberg, Agneta, Goedert, Michel, Scheres, Sjors HW
Published 2023
“.../501100000268 ... : The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G...”

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4

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

by Sakakibara, Yasufumi, Sekiya, Michiko, Saito, Takashi, Takaomi Saido, Iijima, Koichi
Published 2019
“... overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important...”

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5

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

by Sakakibara, Yasufumi, Sekiya, Michiko, Saito, Takashi, Takaomi Saido, Iijima, Koichi
Published 2019
“... overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important...”

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6

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

by Sakakibara, Yasufumi, Sekiya, Michiko, Saito, Takashi, Takaomi Saido, Iijima, Koichi
Published 2018
“... transgenic models that rely on overexpression of amyloid precursor protein (APP). In App-KI mice, three...”

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7

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

by Sakakibara, Yasufumi, Sekiya, Michiko, Saito, Takashi, Takaomi Saido, Iijima, Koichi
Published 2018
“... transgenic models that rely on overexpression of amyloid precursor protein (APP). In App-KI mice, three...”

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8

Die Bedeutung der NMDA-Rezeptoruntereinheit NR2B in der Vermittlung synaptotoxischer Effekte verschiedener Amyloid β-Arten

by Seeser, Franziska Katharina
Published 2018
“... heterozygous NR2B knockout (NR2Bhet), an arctic or swedish mutation in the amyloid precursor protein (Arc) or a...”

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