Search Results - Open Polar - "secretase"

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The Arctic Alzheimer mutation favors intracellular amyloid‐β production by making amyloid precursor protein less available to α‐secretase

by Sahlin, Charlotte, Lord, Anna, Magnusson, Kristina, Englund, Hillevi, Almeida, Claudia G., Greengard, Paul, Nyberg, Fred, Gouras, Gunnar K., Lannfelt, Lars, Nilsson, Lars N.G.
Published in Journal of Neurochemistry (2007)
“... that the Arctic mutation favors proamyloidogenic APP processing by increased β‐secretase cleavage, as demonstrated...”

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Pathogenic Mechanisms of the Arctic Alzheimer Mutation

by Sahlin, Charlotte
Published 2007
“... addressing if and how the mutation affects APP processing. Evidence of a shift towards β-secretase cleavage...”

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Doctoral or Postdoctoral Thesis