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1

Thyroid Gland Remains Responsive to Thyroid Stimulating Hormone With Fasting Duration

by Martinez, Bridget, Soñanez‐Organis, Jose, MacKenzie, Duncan, Crocker, Daniel, Ortiz, Rudy
Published in The FASEB Journal (2015)

“...Food deprivation in mammals is associated with reduced thyroid hormone (TH) to suppress metabolism...”
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2

Thyroidal Regulation of Substrate Metabolism in Fasting Northern Elephant Seal Pups; FASTING, Re-defined

by Martinez, Bridget
Published 2016

Subjects: “...Thyroid gland...”
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Doctoral or Postdoctoral Thesis

3

Increased sensitivity of thyroid hormone-mediated signaling despite prolonged fasting.

by Martinez, Bridget, Scheibner, Michael, Soñanez-Organis, José G, Jaques, John T, Crocker, Daniel E, Ortiz, Rudy M
Published 2017

Subjects: “...Thyroid Hormones...”
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4

Increased Sensitivity of Thyroid Hormone-mediated Signaling Despite Prolonged Fasting

by Martinez, Bridget, Scheibner, Michael, Soñanez-Organis, José G., Jaques, John T., Crocker, Daniel E., Ortiz, Rudy M.
Published in General and Comparative Endocrinology (2017)

“...Thyroid hormones (TH) can increase cellular metabolism. Food deprivation in mammals is typically...”
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5

The Effects and function of the Hypothalamic‐pituitary‐thyroid axis on fasting Northern elephant seals

by Martinez, Bridget, Sonanez, Jose Guadalupe, Rodriguez, Ruben, Viscarra, Jose, Vasquez-Medina, Jose Pablo, Ortiz, Rudy M
Published in The FASEB Journal (2012)

“.... In terrestrial mammals, food deprivation is associated with reduced thyroid hormone (TH) levels and metabolism...”
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6

Deiodinase type 3 methylation increases in response to thyroid stimulating hormone in a fasting adapted mammal

by Martinez, Bridget, Gemmell, Neil, Crocker, Daniel E, Ortiz, Rudy M
Published in The FASEB Journal (2016)

“... driving thyroid hormone triiodothyronine (T3), as a direct consequence of increases in the expression...”
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7

Thyroid hormone changes associated with prolonged food deprivation in adult male northern elephant seals (1101.6)

by Lee, Debby, Martinez, Bridget, Crocker, Daniel, Ortiz, Rudy
Published in The FASEB Journal (2014)

“...During food deprivation in mammals, thyroid hormone (TH) concentrations and deiodinase (DI) content...”
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8

Glucose delays the insulin-induced increase in thyroid hormone-mediated signaling in adipose of prolong-fasted elephant seal pups

by Martinez, Bridget, Soñanez-Organis, José G., Viscarra, Jose A., Jaques, John T., MacKenzie, Duncan S., Crocker, Daniel E., Ortiz, Rudy M.
Published in American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (2016)

“...Prolonged food deprivation in mammals typically reduces glucose, insulin, and thyroid hormone (TH...”
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9

Increases in Thyroid Hormone‐Mediated Plasma Glucose Does Not Stimulate Insulin Secretion in Prolonged‐Fasting Northern Elephant Seal Pups

by Horin, Lillian Jessica, Martinez, Bridget, Crocker, Daniel E, Ortiz, Rudy
Published in The FASEB Journal (2016)

“...‐regulation of cellular thyroid hormone (TH)‐mediated components, insulin, and glucose concentrations. However...”
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10

Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism

by Martinez, Bridget, Soñanez-Organis, José G, Godoy-Lugo, José Arquimides, Horin, Lillian J, Crocker, Daniel E, Ortiz, Rudy M
Published 2017

Subjects: “...Thyroid Hormones...”
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11

Prolonged food deprivation increases mRNA expression of deiodinase 1 and 2, and thyroid hormone receptor β-1 in a fasting-adapted mammal

by Martinez, Bridget, Soñanez-Organis, José G., Vázquez-Medina, José Pablo, Viscarra, Jose A., MacKenzie, Duncan S., Crocker, Daniel E., Ortiz, Rudy M.
Published in Journal of Experimental Biology (2013)

“...Food deprivation in mammals is typically associated with reduced thyroid hormone (TH...”
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12

Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism

by Martinez, Bridget, Soñanez-Organis, José G., Godoy-Lugo, José Arquimides, Horin, Lillian J., Crocker, Daniel E., Ortiz, Rudy M.
Published in American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (2017)

“...Thyroid hormones (THs) regulate metabolism, but are typically suppressed during times of stressful...”
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13

Prolonged food deprivation increases mRNA and protein expression of deiodinase 1 & 2, and thyroid hormone receptor β‐1 in a fasting‐adapted mammal

by Martinez, Bridget, Sonanez, Jose Guadalupe, Ortiz, Rudy M
Published in The FASEB Journal (2013)

“...Food deprivation in mammals is typically associated with reduced [thyroid hormone] (TH...”
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14

Glucose infusion increases mRNA expression of deiodinase 1 & 2, and thyroid hormone receptor β‐1 in a fasting‐adapted mammal (1101.12)

by Martinez, Bridget, Soñanez‐Organis, José, MacKenzie, Duncan, Crocker, Daniel, Ortiz, Rudy
Published in The FASEB Journal (2014)

“...Food deprivation in mammals is typically associated with reduced glucose, thyroid hormone (TH...”
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15

Fasting increases the phosphorylation of AMPK and expression of sirtuin1 in muscle of adult male northern elephant seals (Mirounga angustirostris).

by Lee, Debby, Martinez, Bridget, Crocker, Daniel E, Ortiz, Rudy M
Published 2017

Subjects: “...thyroid hormone...”
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16

Fasting increases the phosphorylation of AMPK and expression of sirtuin1 in muscle of adult male northern elephant seals (Mirounga angustirostris).

by Lee, Debby, Martinez, Bridget, Crocker, Daniel E, Ortiz, Rudy M
Published 2017

Subjects: “...thyroid hormone...”
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17

Adipose transcriptome analysis provides novel insights into molecular regulation of prolonged fasting in northern elephant seal pups

by Martinez, Bridget, Khudyakov, Jane, Rutherford, Kim, Crocker, Daniel E, Gemmell, Neil, Ortiz, Rudy M
Published 2018

“... and energy homeostasis in mammals. Recent studies have highlighted the importance of thyroid hormones...”
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18

Adipose transcriptome analysis provides novel insights into molecular regulation of prolonged fasting in northern elephant seal pups

by Martinez, Bridget, Khudyakov, Jane, Rutherford, Kim, Crocker, Daniel E., Gemmell, Neil, Ortiz, Rudy M.
Published in Physiological Genomics (2018)

“... and energy homeostasis in mammals. Recent studies have highlighted the importance of thyroid hormones...”
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