Search Results

Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.

by Lorenzo Giacani, Sujay Chattopadhyay, Arturo Centurion-Lara, Brendan M Jeffrey, Hoavan T Le, Barbara J Molini, Sheila A Lukehart, Evgeni V Sokurenko, Daniel D Rockey
Published in PLoS Neglected Tropical Diseases (2012)

Analysis of host cell binding specificity mediated by the Tp0136 adhesin of the syphilis agent Treponema pallidum subsp. pallidum.

by Vitomir Djokic, Lorenzo Giacani, Nikhat Parveen
Published in PLOS Neglected Tropical Diseases (2019)

Whole genome sequence of the Treponema pallidum subsp. endemicum strain Bosnia A: the genome is related to yaws treponemes but contains few loci similar to syphilis treponemes.

by Barbora Staudová, Michal Strouhal, Marie Zobaníková, Darina Cejková, Lucinda L Fulton, Lei Chen, Lorenzo Giacani, Arturo Centurion-Lara, Sylvia M Bruisten, Erica Sodergren, George M Weinstock, David Smajs
Published in PLoS Neglected Tropical Diseases (2014)

Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains.

by Arturo Centurion-Lara, Lorenzo Giacani, Charmie Godornes, Barbara J Molini, Tara Brinck Reid, Sheila A Lukehart
Published in PLoS Neglected Tropical Diseases (2013)

Treponema pallidum subsp. pallidum TP0136 protein is heterogeneous among isolates and binds cellular and plasma fibronectin via its NH2-terminal end.

by Wujian Ke, Barbara J Molini, Sheila A Lukehart, Lorenzo Giacani
Published in PLOS Neglected Tropical Diseases (2015)

Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of Treponema pallidum.

by Austin M Haynes, Mark Fernandez, Emily Romeis, Oriol Mitjà, Kelika A Konda, Silver K Vargas, Maria Eguiluz, Carlos F Caceres, Jeffrey D Klausner, Lorenzo Giacani
Published in PLOS Neglected Tropical Diseases (2021)

Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar.

by Nicole A P Lieberman, Michelle J Lin, Hong Xie, Lasata Shrestha, Tien Nguyen, Meei-Li Huang, Austin M Haynes, Emily Romeis, Qian-Qiu Wang, Rui-Li Zhang, Cai-Xia Kou, Giulia Ciccarese, Ivano Dal Conte, Marco Cusini, Francesco Drago, Shu-Ichi Nakayama, Kenichi Lee, Makoto Ohnishi, Kelika A Konda, Silver K Vargas, Maria Eguiluz, Carlos F Caceres, Jeffrey D Klausner, Oriol Mitjà, Anne Rompalo, Fiona Mulcahy, Edward W Hook, Sheila A Lukehart, Amanda M Casto, Pavitra Roychoudhury, Frank DiMaio, Lorenzo Giacani, Alexander L Greninger
Published in PLOS Neglected Tropical Diseases (2021)

Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure.

by Michelle J Lin, Austin M Haynes, Amin Addetia, Nicole A P Lieberman, Quynh Phung, Hong Xie, Tien V Nguyen, Barbara J Molini, Sheila A Lukehart, Lorenzo Giacani, Alexander L Greninger
Published in PLOS Neglected Tropical Diseases (2021)