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Methods to determine the transcriptomes of trypanosomes in mixtures with mammalian cells...

by Julius Mulindwa, Abeer Fadda, Clementine Merce, Enoch Matovu, John Enyaru, Christine Clayton
Published in PLoS Neglected Tropical Diseases (2014)
“... been extensively characterized, and some comparisons have been made with trypanosomes grown to high...”

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Transcriptomes of Trypanosoma brucei rhodesiense from sleeping sickness patients, rodents and culture: Effects of strain, growth conditions and RNA preparation methods.

by Julius Mulindwa, Kevin Leiss, David Ibberson, Kevin Kamanyi Marucha, Claudia Helbig, Larissa Melo do Nascimento, Eleanor Silvester, Keith Matthews, Enock Matovu, John Enyaru, Christine Clayton
Published in PLOS Neglected Tropical Diseases (2018)
“...All of our current knowledge of African trypanosome metabolism is based on results from...”

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3

Stress susceptibility in Trypanosoma brucei lacking the RNA-binding protein ZC3H30.

by Chaitali Chakraborty, Christine Clayton
Published in PLOS Neglected Tropical Diseases (2018)
“...Trypanosomes rely on post-transcriptional mechanisms and mRNA-binding proteins for control of gene...”

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4

Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine.

by Inês Loureiro, Joana Faria, Christine Clayton, Sandra Macedo Ribeiro, Nilanjan Roy, Nuno Santarém, Joana Tavares, Anabela Cordeiro-da-Silva
Published in PLoS Neglected Tropical Diseases (2013)
“... either ammonia or glutamine. The absence of AS-A in humans, and its presence in trypanosomes, suggested...”

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5

Several different sequences are implicated in bloodstream-form-specific gene expression in Trypanosoma brucei.

by Tania Bishola Tshitenge, Lena Reichert, Bin Liu, Christine Clayton
Published in PLOS Neglected Tropical Diseases (2022)
“... forms in tsetse flies. In trypanosomes, gene expression regulation depends heavily on post...”

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Translation Regulation and RNA Granule Formation after Heat Shock of Procyclic Form Trypanosoma brucei: Many Heat-Induced mRNAs Are also Increased during Differentiation to Mammali...

by Igor Minia, Clementine Merce, Monica Terrao, Christine Clayton
Published in PLOS Neglected Tropical Diseases (2016)
“...African trypanosome procyclic forms multiply in the midgut of tsetse flies, and are routinely...”

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7

In vitro culture of freshly isolated Trypanosoma brucei brucei bloodstream forms results in gene copy-number changes.

by Julius Mulindwa, Geofrey Ssentamu, Enock Matovu, Kevin Kamanyi Marucha, Francisco Aresta-Branco, Claudia Helbig, Christine Clayton
Published in PLOS Neglected Tropical Diseases (2021)
“... T. brucei strains should be useful to researchers interested in trypanosome differentiation...”

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