Synthesis of 1,2,3-Triazole Derivatives Based on Propargyl Ester of a Saturated Single-Basic Carbonic Acid and ParaAzidobenzoic Acid
The development of highly effective and low-toxicity nonsteroidal anti-inflammatory drugs (NSAIDs) is one of the important challenges facing modern pharmacology. To overcome this problem, many studies have been conducted on compounds containing a five-membered heterocycle containing three nitrogen a...
Main Author: | |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Zien Journals
2024
|
Subjects: | |
Online Access: | https://zienjournals.com/index.php/tjm/article/view/4910 |
id |
ftzienjourojs:oai:ojs.zienjournals.com:article/4910 |
---|---|
record_format |
openpolar |
spelling |
ftzienjourojs:oai:ojs.zienjournals.com:article/4910 2024-02-11T10:02:52+01:00 Synthesis of 1,2,3-Triazole Derivatives Based on Propargyl Ester of a Saturated Single-Basic Carbonic Acid and ParaAzidobenzoic Acid Fazliddin Kirgizov Bakhtiyarovich 2024-01-18 application/pdf https://zienjournals.com/index.php/tjm/article/view/4910 eng eng Zien Journals https://zienjournals.com/index.php/tjm/article/view/4910/4041 https://zienjournals.com/index.php/tjm/article/view/4910 https://creativecommons.org/licenses/by-nc/4.0 Texas Journal of Multidisciplinary Studies; Vol. 28 (2024): TJM; 4-11 2770-0003 course inflammatory presence catalyst info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article 2024 ftzienjourojs 2024-01-25T18:58:44Z The development of highly effective and low-toxicity nonsteroidal anti-inflammatory drugs (NSAIDs) is one of the important challenges facing modern pharmacology. To overcome this problem, many studies have been conducted on compounds containing a five-membered heterocycle containing three nitrogen atoms. The pharmacodynamics of these compounds are mainly due to their anti-inflammatory effect. Therefore, it is important to synthesize new derivatives of 1,2,3-triazoles, to determine their structure and to look for substances with anti-inflammatory activity on their basis. For the first time, the corresponding derivatives of 4-(4-(exchangeable)-1H-1,2,3-triazole-1-yl)-benzoic acid were synthesized by cycloaddition of propargyl esters of saturated carboxylic acids and para-azidobenzoic acid in the presence of copper (I) iodide. The structure of the obtained substances was analyzed by IR, 1H NMR, and MS techniques. It is proved that under the action of the catalyst in the reaction, only 1,4-isomers are formed. Factors affecting the course of the reaction were identified. Article in Journal/Newspaper Carbonic acid Zien Journals |
institution |
Open Polar |
collection |
Zien Journals |
op_collection_id |
ftzienjourojs |
language |
English |
topic |
course inflammatory presence catalyst |
spellingShingle |
course inflammatory presence catalyst Fazliddin Kirgizov Bakhtiyarovich Synthesis of 1,2,3-Triazole Derivatives Based on Propargyl Ester of a Saturated Single-Basic Carbonic Acid and ParaAzidobenzoic Acid |
topic_facet |
course inflammatory presence catalyst |
description |
The development of highly effective and low-toxicity nonsteroidal anti-inflammatory drugs (NSAIDs) is one of the important challenges facing modern pharmacology. To overcome this problem, many studies have been conducted on compounds containing a five-membered heterocycle containing three nitrogen atoms. The pharmacodynamics of these compounds are mainly due to their anti-inflammatory effect. Therefore, it is important to synthesize new derivatives of 1,2,3-triazoles, to determine their structure and to look for substances with anti-inflammatory activity on their basis. For the first time, the corresponding derivatives of 4-(4-(exchangeable)-1H-1,2,3-triazole-1-yl)-benzoic acid were synthesized by cycloaddition of propargyl esters of saturated carboxylic acids and para-azidobenzoic acid in the presence of copper (I) iodide. The structure of the obtained substances was analyzed by IR, 1H NMR, and MS techniques. It is proved that under the action of the catalyst in the reaction, only 1,4-isomers are formed. Factors affecting the course of the reaction were identified. |
format |
Article in Journal/Newspaper |
author |
Fazliddin Kirgizov Bakhtiyarovich |
author_facet |
Fazliddin Kirgizov Bakhtiyarovich |
author_sort |
Fazliddin Kirgizov Bakhtiyarovich |
title |
Synthesis of 1,2,3-Triazole Derivatives Based on Propargyl Ester of a Saturated Single-Basic Carbonic Acid and ParaAzidobenzoic Acid |
title_short |
Synthesis of 1,2,3-Triazole Derivatives Based on Propargyl Ester of a Saturated Single-Basic Carbonic Acid and ParaAzidobenzoic Acid |
title_full |
Synthesis of 1,2,3-Triazole Derivatives Based on Propargyl Ester of a Saturated Single-Basic Carbonic Acid and ParaAzidobenzoic Acid |
title_fullStr |
Synthesis of 1,2,3-Triazole Derivatives Based on Propargyl Ester of a Saturated Single-Basic Carbonic Acid and ParaAzidobenzoic Acid |
title_full_unstemmed |
Synthesis of 1,2,3-Triazole Derivatives Based on Propargyl Ester of a Saturated Single-Basic Carbonic Acid and ParaAzidobenzoic Acid |
title_sort |
synthesis of 1,2,3-triazole derivatives based on propargyl ester of a saturated single-basic carbonic acid and paraazidobenzoic acid |
publisher |
Zien Journals |
publishDate |
2024 |
url |
https://zienjournals.com/index.php/tjm/article/view/4910 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Texas Journal of Multidisciplinary Studies; Vol. 28 (2024): TJM; 4-11 2770-0003 |
op_relation |
https://zienjournals.com/index.php/tjm/article/view/4910/4041 https://zienjournals.com/index.php/tjm/article/view/4910 |
op_rights |
https://creativecommons.org/licenses/by-nc/4.0 |
_version_ |
1790598952146436096 |