Relationship between red blood cell lifespan and endogenous carbon monoxide in the common bottlenose dolphin and beluga
Certain deep-diving marine mammals (i.e., northern elephant seal (Mirounga angustirosis), Weddell seal (Leptonychotes weddellii)) have blood carbon monoxide (CO) levels that are comparable to those of chronic cigarette smokers. Most CO produced in humans is a by-product of heme degradation, which is...
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ftzenodo:oai:zenodo.org:8326027 2023-10-29T02:35:20+01:00 Relationship between red blood cell lifespan and endogenous carbon monoxide in the common bottlenose dolphin and beluga Anna B. Pearson Luis A. Huckstadt Stephen T. Kinsey Todd L. Schmitt Todd R. Robeck Judy St. Leger Paul J. Ponganis Michael S. Tift 2023-09-07 https://zenodo.org/record/8326027 https://doi.org/10.5281/zenodo.8326027 unknown doi:10.5281/zenodo.8326026 https://zenodo.org/record/8326027 https://doi.org/10.5281/zenodo.8326027 oai:zenodo.org:8326027 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode info:eu-repo/semantics/article publication-article 2023 ftzenodo https://doi.org/10.5281/zenodo.832602710.5281/zenodo.8326026 2023-10-03T22:58:26Z Certain deep-diving marine mammals (i.e., northern elephant seal (Mirounga angustirosis), Weddell seal (Leptonychotes weddellii)) have blood carbon monoxide (CO) levels that are comparable to those of chronic cigarette smokers. Most CO produced in humans is a by-product of heme degradation, which is released when red blood cells (RBC) are destroyed. Elevated CO can occur in humans when RBC lifespan decreases. The contribution of RBC turnover to CO concentrations in marine mammals is unknown. Here, we report the first RBC lifespans in two healthy, marine mammal species with different diving capacities and heme stores, the shallow diving bottlenose dolphin (Tursiops truncatus) and deep-diving beluga (Delphinapterus leucas) and relate the lifespans to the levels of CO in blood and breath. The belugas, with high blood heme stores, had the longest mean RBC lifespan compared to humans and bottlenose dolphins. Both cetacean species were found to have three times higher blood CO content compared to humans. The estimated CO production rate from heme degradation indicates some marine mammals may have additional mechanisms for CO production, or delay CO removal from the body, potentially from long duration breath-holds. Article in Journal/Newspaper Beluga Beluga* Delphinapterus leucas Elephant Seal Weddell Seal Zenodo |
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Certain deep-diving marine mammals (i.e., northern elephant seal (Mirounga angustirosis), Weddell seal (Leptonychotes weddellii)) have blood carbon monoxide (CO) levels that are comparable to those of chronic cigarette smokers. Most CO produced in humans is a by-product of heme degradation, which is released when red blood cells (RBC) are destroyed. Elevated CO can occur in humans when RBC lifespan decreases. The contribution of RBC turnover to CO concentrations in marine mammals is unknown. Here, we report the first RBC lifespans in two healthy, marine mammal species with different diving capacities and heme stores, the shallow diving bottlenose dolphin (Tursiops truncatus) and deep-diving beluga (Delphinapterus leucas) and relate the lifespans to the levels of CO in blood and breath. The belugas, with high blood heme stores, had the longest mean RBC lifespan compared to humans and bottlenose dolphins. Both cetacean species were found to have three times higher blood CO content compared to humans. The estimated CO production rate from heme degradation indicates some marine mammals may have additional mechanisms for CO production, or delay CO removal from the body, potentially from long duration breath-holds. |
format |
Article in Journal/Newspaper |
author |
Anna B. Pearson Luis A. Huckstadt Stephen T. Kinsey Todd L. Schmitt Todd R. Robeck Judy St. Leger Paul J. Ponganis Michael S. Tift |
spellingShingle |
Anna B. Pearson Luis A. Huckstadt Stephen T. Kinsey Todd L. Schmitt Todd R. Robeck Judy St. Leger Paul J. Ponganis Michael S. Tift Relationship between red blood cell lifespan and endogenous carbon monoxide in the common bottlenose dolphin and beluga |
author_facet |
Anna B. Pearson Luis A. Huckstadt Stephen T. Kinsey Todd L. Schmitt Todd R. Robeck Judy St. Leger Paul J. Ponganis Michael S. Tift |
author_sort |
Anna B. Pearson |
title |
Relationship between red blood cell lifespan and endogenous carbon monoxide in the common bottlenose dolphin and beluga |
title_short |
Relationship between red blood cell lifespan and endogenous carbon monoxide in the common bottlenose dolphin and beluga |
title_full |
Relationship between red blood cell lifespan and endogenous carbon monoxide in the common bottlenose dolphin and beluga |
title_fullStr |
Relationship between red blood cell lifespan and endogenous carbon monoxide in the common bottlenose dolphin and beluga |
title_full_unstemmed |
Relationship between red blood cell lifespan and endogenous carbon monoxide in the common bottlenose dolphin and beluga |
title_sort |
relationship between red blood cell lifespan and endogenous carbon monoxide in the common bottlenose dolphin and beluga |
publishDate |
2023 |
url |
https://zenodo.org/record/8326027 https://doi.org/10.5281/zenodo.8326027 |
genre |
Beluga Beluga* Delphinapterus leucas Elephant Seal Weddell Seal |
genre_facet |
Beluga Beluga* Delphinapterus leucas Elephant Seal Weddell Seal |
op_relation |
doi:10.5281/zenodo.8326026 https://zenodo.org/record/8326027 https://doi.org/10.5281/zenodo.8326027 oai:zenodo.org:8326027 |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode |
op_doi |
https://doi.org/10.5281/zenodo.832602710.5281/zenodo.8326026 |
_version_ |
1781058457080692736 |