Fig. 7 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production

• Main Authors: Cong, Mengjing, Ren, Xue, Song, Yue, Pang, Xiaoyan, Tian, Xinpeng, Liu, Yonghong, Guo, Peng, Wang, Junfeng
• Format: Other/Unknown Material
• Language: unknown
• Published: Zenodo 2023
• Subjects: Biodiversity; Taxonomy; Antarc*; Antarctic; ren
• Online Access: https://doi.org/10.5281/zenodo.8230347

Fig. 7. Anti-inflammation activity of ochrathinols A and B ((±)-1, (±)-2). Cells were exposed to 0.1 μg/mL LPS and co-treated with compounds of (+)-1, ()-1, (±)-1, (+)-2, ()-2, (±)-2 (10 μM) for 24 h, respectively. (A) (±)-1 reduced the release of LPS-induced IL-6, TNF-α, and MCP-1 in culture medium, n = 3. (B) qPCR analysis of pro-inflammatory cytokines genes (IL-1β, IL-6, TNF-α, and MCP-1) normalized by β-actin, n = 3. All data are presented as the mean ± SD of three independent experiments. ns, P> 0.05, *P <0.05, **P <0.01, ***P <0.005, ****P <0.001 vs. LPS group; #P <0.05, ##P <0.01, ###P <0.005, ####P <0.001 vs. control group, n = 3. P value was assessed by two-tailed Student's t-test. Published as part of Cong, Mengjing, Ren, Xue, Song, Yue, Pang, Xiaoyan, Tian, Xinpeng, Liu, Yonghong, Guo, Peng & Wang, Junfeng, 2023, Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production, pp. 1-8 in Phytochemistry (113593) 208 on page 5, DOI:10.1016/j.phytochem.2023.113593, http://zenodo.org/record/8230332