Supporting Data for: The genome of the pygmy right whale illuminates the evolution of rorquals
Background Baleen whales are a clade of gigantic and highly specialized marine mammals. Their genomes have been used to investigate their complex evolutionary history and to decipher the molecular mechanisms that allowed them to reach these dimensions. However, many unanswered questions remain, espe...
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ftzenodo:oai:zenodo.org:7768603 2023-10-29T02:35:14+01:00 Supporting Data for: The genome of the pygmy right whale illuminates the evolution of rorquals Wolf, Magnus Zapf, Konstantin Gupta, Deepak Kumar Hiller, Michael Árnason, Ulfur Janke, Axel 2023-03-24 https://zenodo.org/record/7768603 https://doi.org/10.5061/dryad.9zw3r22j0 unknown https://github.com/mag-wolf/GEMOMA-to-Phylogeny doi:10.1186/s12915-023-01579-1 doi:10.5281/zenodo.7740016 https://zenodo.org/communities/dryad https://zenodo.org/record/7768603 https://doi.org/10.5061/dryad.9zw3r22j0 oai:zenodo.org:7768603 info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode Pygmy right whale Caperea marginata whole genome sequencing Phylogenomics rorquals positive selection Cancer resistance Peto's paradox genome assembly de novo genome baleen whale whale Mysticeti Introgression Cell biology Developmental biology Plant science General Agricultural and Biological Sciences General Biochemistry Genetics and Molecular Biology Physiology Ecology Evolution Behavior and Systematics structural biology Biotechnology info:eu-repo/semantics/other dataset 2023 ftzenodo https://doi.org/10.5061/dryad.9zw3r22j010.1186/s12915-023-01579-110.5281/zenodo.7740016 2023-10-03T22:57:43Z Background Baleen whales are a clade of gigantic and highly specialized marine mammals. Their genomes have been used to investigate their complex evolutionary history and to decipher the molecular mechanisms that allowed them to reach these dimensions. However, many unanswered questions remain, especially about the early radiation of rorquals and how cancer resistance interplays with their huge number of cells. The pygmy right whale is the smallest and most elusive among the baleen whales. It reaches only a fraction of the body length compared to its relatives and it is the only living member of an otherwise extinct family. This placement makes the pygmy right whale genome an interesting target to update the complex phylogenetic past of baleen whales, because it splits up an otherwise long branch that leads to the radiation of rorquals. Apart from that, genomic data of this species might help to investigate cancer resistance in large whales, since these mechanisms are not as important for the pygmy right whale as in other giant rorquals and right whales. Results Here, we present a first de novo genome of the species and test its potential in phylogenomics and cancer research. To do so, we constructed a multi-species coalescent tree from fragments of a whole-genome alignment and quantified the amount of introgression in the early evolution of rorquals. Furthermore, a genome wide comparison of selection rates between large and small bodied baleen whales revealed a small set of conserved candidate genes with potential connections to cancer resistance. Conclusions Our results suggest that the evolution of rorquals is best described as a hard polytomy with a rapid radiation and high levels of introgression. The lack of shared positive selected genes between different large-bodied whale species supports a previously proposed convergent evolution of gigantism and hence cancer resistance in baleen whales. General Usage: Many files containing sequence data are zipped using gzip. Use "gunzip" to reverse this. Also, ... Dataset baleen whale baleen whales Zenodo |
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unknown |
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Pygmy right whale Caperea marginata whole genome sequencing Phylogenomics rorquals positive selection Cancer resistance Peto's paradox genome assembly de novo genome baleen whale whale Mysticeti Introgression Cell biology Developmental biology Plant science General Agricultural and Biological Sciences General Biochemistry Genetics and Molecular Biology Physiology Ecology Evolution Behavior and Systematics structural biology Biotechnology |
spellingShingle |
Pygmy right whale Caperea marginata whole genome sequencing Phylogenomics rorquals positive selection Cancer resistance Peto's paradox genome assembly de novo genome baleen whale whale Mysticeti Introgression Cell biology Developmental biology Plant science General Agricultural and Biological Sciences General Biochemistry Genetics and Molecular Biology Physiology Ecology Evolution Behavior and Systematics structural biology Biotechnology Wolf, Magnus Zapf, Konstantin Gupta, Deepak Kumar Hiller, Michael Árnason, Ulfur Janke, Axel Supporting Data for: The genome of the pygmy right whale illuminates the evolution of rorquals |
topic_facet |
Pygmy right whale Caperea marginata whole genome sequencing Phylogenomics rorquals positive selection Cancer resistance Peto's paradox genome assembly de novo genome baleen whale whale Mysticeti Introgression Cell biology Developmental biology Plant science General Agricultural and Biological Sciences General Biochemistry Genetics and Molecular Biology Physiology Ecology Evolution Behavior and Systematics structural biology Biotechnology |
description |
Background Baleen whales are a clade of gigantic and highly specialized marine mammals. Their genomes have been used to investigate their complex evolutionary history and to decipher the molecular mechanisms that allowed them to reach these dimensions. However, many unanswered questions remain, especially about the early radiation of rorquals and how cancer resistance interplays with their huge number of cells. The pygmy right whale is the smallest and most elusive among the baleen whales. It reaches only a fraction of the body length compared to its relatives and it is the only living member of an otherwise extinct family. This placement makes the pygmy right whale genome an interesting target to update the complex phylogenetic past of baleen whales, because it splits up an otherwise long branch that leads to the radiation of rorquals. Apart from that, genomic data of this species might help to investigate cancer resistance in large whales, since these mechanisms are not as important for the pygmy right whale as in other giant rorquals and right whales. Results Here, we present a first de novo genome of the species and test its potential in phylogenomics and cancer research. To do so, we constructed a multi-species coalescent tree from fragments of a whole-genome alignment and quantified the amount of introgression in the early evolution of rorquals. Furthermore, a genome wide comparison of selection rates between large and small bodied baleen whales revealed a small set of conserved candidate genes with potential connections to cancer resistance. Conclusions Our results suggest that the evolution of rorquals is best described as a hard polytomy with a rapid radiation and high levels of introgression. The lack of shared positive selected genes between different large-bodied whale species supports a previously proposed convergent evolution of gigantism and hence cancer resistance in baleen whales. General Usage: Many files containing sequence data are zipped using gzip. Use "gunzip" to reverse this. Also, ... |
format |
Dataset |
author |
Wolf, Magnus Zapf, Konstantin Gupta, Deepak Kumar Hiller, Michael Árnason, Ulfur Janke, Axel |
author_facet |
Wolf, Magnus Zapf, Konstantin Gupta, Deepak Kumar Hiller, Michael Árnason, Ulfur Janke, Axel |
author_sort |
Wolf, Magnus |
title |
Supporting Data for: The genome of the pygmy right whale illuminates the evolution of rorquals |
title_short |
Supporting Data for: The genome of the pygmy right whale illuminates the evolution of rorquals |
title_full |
Supporting Data for: The genome of the pygmy right whale illuminates the evolution of rorquals |
title_fullStr |
Supporting Data for: The genome of the pygmy right whale illuminates the evolution of rorquals |
title_full_unstemmed |
Supporting Data for: The genome of the pygmy right whale illuminates the evolution of rorquals |
title_sort |
supporting data for: the genome of the pygmy right whale illuminates the evolution of rorquals |
publishDate |
2023 |
url |
https://zenodo.org/record/7768603 https://doi.org/10.5061/dryad.9zw3r22j0 |
genre |
baleen whale baleen whales |
genre_facet |
baleen whale baleen whales |
op_relation |
https://github.com/mag-wolf/GEMOMA-to-Phylogeny doi:10.1186/s12915-023-01579-1 doi:10.5281/zenodo.7740016 https://zenodo.org/communities/dryad https://zenodo.org/record/7768603 https://doi.org/10.5061/dryad.9zw3r22j0 oai:zenodo.org:7768603 |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.9zw3r22j010.1186/s12915-023-01579-110.5281/zenodo.7740016 |
_version_ |
1781058291267272704 |