Tropism of Highly Pathogenic Avian Influenza H5 Viruses from the 2020/2021 Epizootic in Wild Ducks and Geese
Highly pathogenic avian influenza (HPAI) outbreaks have become increasingly frequent in wild bird populations and have caused mass mortality in many wild bird species. The 2020/2021 epizootic was the largest and most deadly ever reported in Europe, and many new bird species tested positive for HPAI...
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ftzenodo:oai:zenodo.org:7547216 2024-09-15T17:58:04+00:00 Tropism of Highly Pathogenic Avian Influenza H5 Viruses from the 2020/2021 Epizootic in Wild Ducks and Geese Caliendo, V. Leijten, L. van de Bildt, M. W. Germeraad, E. Fouchier, R. A. Beerens, N. Kuiken, T. 2023-01-18 https://doi.org/10.3390/v14020280 unknown Zenodo https://doi.org/10.3390/v14020280 oai:zenodo.org:7547216 info:eu-repo/semantics/openAccess Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode avian influenza HPAI H5N8 Eurasian wigeon barnacle goose enterotropism neurotropism info:eu-repo/semantics/article 2023 ftzenodo https://doi.org/10.3390/v14020280 2024-07-25T16:18:04Z Highly pathogenic avian influenza (HPAI) outbreaks have become increasingly frequent in wild bird populations and have caused mass mortality in many wild bird species. The 2020/2021 epizootic was the largest and most deadly ever reported in Europe, and many new bird species tested positive for HPAI virus for the first time. This study investigated the tropism of HPAI virus in wild birds. We tested the pattern of virus attachment of 2020 H5N8 virus to intestinal and respiratory tissues of key bird species; and characterized pathology of naturally infected Eurasian wigeons (Mareca penelope) and barnacle geese (Branta leucopsis). This study determined that 2020 H5N8 virus had a high level of attachment to the intestinal epithelium (enterotropism) of dabbling ducks and geese and retained attachment to airway epithelium (respirotropism). Natural HPAI 2020 H5 virus infection in Eurasian wigeons and barnacle geese also showed a high level of neurotropism, as both species presented with brain lesions that co-localized with virus antigen expression. We concluded that the combination of respirotropism, neurotropism, and possibly enterotropism, contributed to the successful adaptation of 2020/2021 HPAI H5 viruses to wild waterbird populations. Article in Journal/Newspaper Barnacle goose Branta leucopsis Zenodo Viruses 14 2 280 |
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unknown |
topic |
avian influenza HPAI H5N8 Eurasian wigeon barnacle goose enterotropism neurotropism |
spellingShingle |
avian influenza HPAI H5N8 Eurasian wigeon barnacle goose enterotropism neurotropism Caliendo, V. Leijten, L. van de Bildt, M. W. Germeraad, E. Fouchier, R. A. Beerens, N. Kuiken, T. Tropism of Highly Pathogenic Avian Influenza H5 Viruses from the 2020/2021 Epizootic in Wild Ducks and Geese |
topic_facet |
avian influenza HPAI H5N8 Eurasian wigeon barnacle goose enterotropism neurotropism |
description |
Highly pathogenic avian influenza (HPAI) outbreaks have become increasingly frequent in wild bird populations and have caused mass mortality in many wild bird species. The 2020/2021 epizootic was the largest and most deadly ever reported in Europe, and many new bird species tested positive for HPAI virus for the first time. This study investigated the tropism of HPAI virus in wild birds. We tested the pattern of virus attachment of 2020 H5N8 virus to intestinal and respiratory tissues of key bird species; and characterized pathology of naturally infected Eurasian wigeons (Mareca penelope) and barnacle geese (Branta leucopsis). This study determined that 2020 H5N8 virus had a high level of attachment to the intestinal epithelium (enterotropism) of dabbling ducks and geese and retained attachment to airway epithelium (respirotropism). Natural HPAI 2020 H5 virus infection in Eurasian wigeons and barnacle geese also showed a high level of neurotropism, as both species presented with brain lesions that co-localized with virus antigen expression. We concluded that the combination of respirotropism, neurotropism, and possibly enterotropism, contributed to the successful adaptation of 2020/2021 HPAI H5 viruses to wild waterbird populations. |
format |
Article in Journal/Newspaper |
author |
Caliendo, V. Leijten, L. van de Bildt, M. W. Germeraad, E. Fouchier, R. A. Beerens, N. Kuiken, T. |
author_facet |
Caliendo, V. Leijten, L. van de Bildt, M. W. Germeraad, E. Fouchier, R. A. Beerens, N. Kuiken, T. |
author_sort |
Caliendo, V. |
title |
Tropism of Highly Pathogenic Avian Influenza H5 Viruses from the 2020/2021 Epizootic in Wild Ducks and Geese |
title_short |
Tropism of Highly Pathogenic Avian Influenza H5 Viruses from the 2020/2021 Epizootic in Wild Ducks and Geese |
title_full |
Tropism of Highly Pathogenic Avian Influenza H5 Viruses from the 2020/2021 Epizootic in Wild Ducks and Geese |
title_fullStr |
Tropism of Highly Pathogenic Avian Influenza H5 Viruses from the 2020/2021 Epizootic in Wild Ducks and Geese |
title_full_unstemmed |
Tropism of Highly Pathogenic Avian Influenza H5 Viruses from the 2020/2021 Epizootic in Wild Ducks and Geese |
title_sort |
tropism of highly pathogenic avian influenza h5 viruses from the 2020/2021 epizootic in wild ducks and geese |
publisher |
Zenodo |
publishDate |
2023 |
url |
https://doi.org/10.3390/v14020280 |
genre |
Barnacle goose Branta leucopsis |
genre_facet |
Barnacle goose Branta leucopsis |
op_relation |
https://doi.org/10.3390/v14020280 oai:zenodo.org:7547216 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode |
op_doi |
https://doi.org/10.3390/v14020280 |
container_title |
Viruses |
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14 |
container_issue |
2 |
container_start_page |
280 |
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1810434286152581120 |