Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae)
Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological as well as behavioral differences. Each species has had its own evolutionary trajectory, formed by many types of selection pressures and ra...
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ftzenodo:oai:zenodo.org:7131709 2024-09-15T18:17:47+00:00 Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko 2022-09-29 https://doi.org/10.5061/dryad.p8cz8w9sm unknown Zenodo https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.p8cz8w9sm oai:zenodo.org:7131709 info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode speciation Genome metabolism Animal evolution Lepus Lepus timidus Lepus europaeus info:eu-repo/semantics/other 2022 ftzenodo https://doi.org/10.5061/dryad.p8cz8w9sm 2024-07-27T06:28:59Z Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological as well as behavioral differences. Each species has had its own evolutionary trajectory, formed by many types of selection pressures and random drift, making it extremely complicated to associate genetic differences between the species with the phenotypic differences. In the present study, we have used an in vitro model to analyze in depth the genetic and gene regulation differences between fibroblasts of two closely related mammals, arctic/subarctic mountain hare (Lepus timidus Linnaeus) and a temperate, steppe-like climate adapted brown hare (Lepus europaeus Pallas). We discovered the existence of a species-specific expression pattern of 1,623 genes, manifesting in differences in cell growth, respiration, and metabolism. Interspecific differences in the housekeeping functions of fibroblast cells suggest speciation acts on fundamental processes, even in these two interfertile species. Our results help to understand the molecular constituents of a species difference on a cellular level, which could contribute to the maintenance of the species boundary. Funding provided by: Academy of Finland Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002341 Award Number: 329264 Other/Unknown Material Lepus timidus mountain hare Subarctic Zenodo |
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topic |
speciation Genome metabolism Animal evolution Lepus Lepus timidus Lepus europaeus |
spellingShingle |
speciation Genome metabolism Animal evolution Lepus Lepus timidus Lepus europaeus Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
topic_facet |
speciation Genome metabolism Animal evolution Lepus Lepus timidus Lepus europaeus |
description |
Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological as well as behavioral differences. Each species has had its own evolutionary trajectory, formed by many types of selection pressures and random drift, making it extremely complicated to associate genetic differences between the species with the phenotypic differences. In the present study, we have used an in vitro model to analyze in depth the genetic and gene regulation differences between fibroblasts of two closely related mammals, arctic/subarctic mountain hare (Lepus timidus Linnaeus) and a temperate, steppe-like climate adapted brown hare (Lepus europaeus Pallas). We discovered the existence of a species-specific expression pattern of 1,623 genes, manifesting in differences in cell growth, respiration, and metabolism. Interspecific differences in the housekeeping functions of fibroblast cells suggest speciation acts on fundamental processes, even in these two interfertile species. Our results help to understand the molecular constituents of a species difference on a cellular level, which could contribute to the maintenance of the species boundary. Funding provided by: Academy of Finland Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100002341 Award Number: 329264 |
format |
Other/Unknown Material |
author |
Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko |
author_facet |
Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko |
author_sort |
Gaertner, Kateryna |
title |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_short |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_full |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_fullStr |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_full_unstemmed |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_sort |
molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (lepus spp., lagomorpha: leporidae) |
publisher |
Zenodo |
publishDate |
2022 |
url |
https://doi.org/10.5061/dryad.p8cz8w9sm |
genre |
Lepus timidus mountain hare Subarctic |
genre_facet |
Lepus timidus mountain hare Subarctic |
op_relation |
https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.p8cz8w9sm oai:zenodo.org:7131709 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.p8cz8w9sm |
_version_ |
1810455876797988864 |