Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses
Emerging and re-emerging viruses represent a serious threat to human health at a global level. In particular, enveloped viruses are one of the main causes of viral outbreaks, as recently demonstrated by SARS-CoV-2. An effective strategy to counteract these viruses could be to target the envelope by...
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ftzenodo:oai:zenodo.org:5827724 2024-09-15T17:42:41+00:00 Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses Giugliano Rosa Buonocore Carmine Zannella Carla Chianese Annalisa Esposito Fortunato Palma Tedesco Pietro De Filippis Anna Galdiero Massimiliano Franci Gianluigi de Pascale Donatella 2021-12-08 https://doi.org/10.3390/pharmaceutics13122121 unknown Zenodo https://zenodo.org/communities/eu https://doi.org/10.3390/pharmaceutics13122121 oai:zenodo.org:5827724 info:eu-repo/semantics/openAccess Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode Pharmaceutics, 13(12), (2021-12-08) microbial biosurfactants rhamnolipids antiviral SARS-CoV-2 enveloped virus coronavirus herpes Antarctic bacteria TEM info:eu-repo/semantics/article 2021 ftzenodo https://doi.org/10.3390/pharmaceutics13122121 2024-07-25T09:05:18Z Emerging and re-emerging viruses represent a serious threat to human health at a global level. In particular, enveloped viruses are one of the main causes of viral outbreaks, as recently demonstrated by SARS-CoV-2. An effective strategy to counteract these viruses could be to target the envelope by using surface-active compounds. Rhamnolipids (RLs) are microbial biosurfactants displaying a wide range of bioactivities, such as antibacterial, antifungal and antibiofilm, among others. Being of microbial origin, they are environmentally-friendly, biodegradable, and less toxic than synthetic surfactants. In this work, we explored the antiviral activity of the rhamnolipids mixture (M15RL) produced by the Antarctic bacteria Pseudomonas gessardii M15 against viruses belonging to Coronaviridae and Herpesviridae families. In addition, we investigated the rhamnolipids’ mode of action and the possibility of inactivating viruses on treated surfaces. Our results show complete inactivation of HSV-1 and HSV-2 by M15RLs at 6 µg/mL, and of HCoV-229E and SARSCoV-2 at 25 and 50 µg/mL, respectively. Concerning activity against HCoV-OC43, 80% inhibition of cytopathic effect was recorded, while no activity against naked Poliovirus Type 1 (PV-1) was detectable, suggesting that the antiviral action is mainly directed towards the envelope. In conclusion, we report a significant activity of M15RL against enveloped viruses and demonstrated for the first time the antiviral effect of rhamnolipids against SARS-CoV-2. Article in Journal/Newspaper Antarc* Antarctic Zenodo Pharmaceutics 13 12 2121 |
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ftzenodo |
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unknown |
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microbial biosurfactants rhamnolipids antiviral SARS-CoV-2 enveloped virus coronavirus herpes Antarctic bacteria TEM |
spellingShingle |
microbial biosurfactants rhamnolipids antiviral SARS-CoV-2 enveloped virus coronavirus herpes Antarctic bacteria TEM Giugliano Rosa Buonocore Carmine Zannella Carla Chianese Annalisa Esposito Fortunato Palma Tedesco Pietro De Filippis Anna Galdiero Massimiliano Franci Gianluigi de Pascale Donatella Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses |
topic_facet |
microbial biosurfactants rhamnolipids antiviral SARS-CoV-2 enveloped virus coronavirus herpes Antarctic bacteria TEM |
description |
Emerging and re-emerging viruses represent a serious threat to human health at a global level. In particular, enveloped viruses are one of the main causes of viral outbreaks, as recently demonstrated by SARS-CoV-2. An effective strategy to counteract these viruses could be to target the envelope by using surface-active compounds. Rhamnolipids (RLs) are microbial biosurfactants displaying a wide range of bioactivities, such as antibacterial, antifungal and antibiofilm, among others. Being of microbial origin, they are environmentally-friendly, biodegradable, and less toxic than synthetic surfactants. In this work, we explored the antiviral activity of the rhamnolipids mixture (M15RL) produced by the Antarctic bacteria Pseudomonas gessardii M15 against viruses belonging to Coronaviridae and Herpesviridae families. In addition, we investigated the rhamnolipids’ mode of action and the possibility of inactivating viruses on treated surfaces. Our results show complete inactivation of HSV-1 and HSV-2 by M15RLs at 6 µg/mL, and of HCoV-229E and SARSCoV-2 at 25 and 50 µg/mL, respectively. Concerning activity against HCoV-OC43, 80% inhibition of cytopathic effect was recorded, while no activity against naked Poliovirus Type 1 (PV-1) was detectable, suggesting that the antiviral action is mainly directed towards the envelope. In conclusion, we report a significant activity of M15RL against enveloped viruses and demonstrated for the first time the antiviral effect of rhamnolipids against SARS-CoV-2. |
format |
Article in Journal/Newspaper |
author |
Giugliano Rosa Buonocore Carmine Zannella Carla Chianese Annalisa Esposito Fortunato Palma Tedesco Pietro De Filippis Anna Galdiero Massimiliano Franci Gianluigi de Pascale Donatella |
author_facet |
Giugliano Rosa Buonocore Carmine Zannella Carla Chianese Annalisa Esposito Fortunato Palma Tedesco Pietro De Filippis Anna Galdiero Massimiliano Franci Gianluigi de Pascale Donatella |
author_sort |
Giugliano Rosa |
title |
Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses |
title_short |
Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses |
title_full |
Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses |
title_fullStr |
Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses |
title_full_unstemmed |
Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses |
title_sort |
antiviral activity of the rhamnolipids mixture from the antarctic bacterium pseudomonas gessardii m15 against herpes simplex viruses and coronaviruses |
publisher |
Zenodo |
publishDate |
2021 |
url |
https://doi.org/10.3390/pharmaceutics13122121 |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Pharmaceutics, 13(12), (2021-12-08) |
op_relation |
https://zenodo.org/communities/eu https://doi.org/10.3390/pharmaceutics13122121 oai:zenodo.org:5827724 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode |
op_doi |
https://doi.org/10.3390/pharmaceutics13122121 |
container_title |
Pharmaceutics |
container_volume |
13 |
container_issue |
12 |
container_start_page |
2121 |
_version_ |
1810489389955940352 |