Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow
Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller's descriptions with paleogenomic data from 12 individuals. We identified convergent evolution betwe...
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ftzenodo:oai:zenodo.org:5665275 2024-09-15T18:37:42+00:00 Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow Velluva, Akhil Le Duc, Diana Cassatt-Johnstone, Molly Olsen, Remi-Andre Baleka, Sina Lin, Chen-Ching R. Lemke, Johannes R. Southon, John Burdin, Alexander Wang, Ming-Shan Grunewald, Sonja Rosendahl, Wilfried Joger, Ulrich Rutschmann, Sereina B. Hildebrandt, Thomas Fritsch, Guido A. Estes, James Kelso, Janet Dalén, Love Hofreiter, Michael Shapiro, Beth Schöneberg, Torsten 2021-11-24 https://doi.org/10.5281/zenodo.5665275 unknown Zenodo https://doi.org/10.5061/dryad.cc2fqz673 https://zenodo.org/communities/dryad https://doi.org/10.5281/zenodo.5665274 https://doi.org/10.5281/zenodo.5665275 oai:zenodo.org:5665275 info:eu-repo/semantics/openAccess Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode info:eu-repo/semantics/other 2021 ftzenodo https://doi.org/10.5281/zenodo.566527510.5061/dryad.cc2fqz67310.5281/zenodo.5665274 2024-07-26T23:17:24Z Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller's descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller's sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse models cause ichthyosis – a skin disease characterized by a thick, hyperkeratotic epidermis that recapitulates Steller's sea cows' reportedly bark-like skin. Finally, we found that Steller's sea cows' abundance was continuously declining for tens of thousands of years prior to their description, implying that environmental changes also contributed to their extinction. Other/Unknown Material Steller's sea cow Zenodo |
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description |
Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller's descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller's sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse models cause ichthyosis – a skin disease characterized by a thick, hyperkeratotic epidermis that recapitulates Steller's sea cows' reportedly bark-like skin. Finally, we found that Steller's sea cows' abundance was continuously declining for tens of thousands of years prior to their description, implying that environmental changes also contributed to their extinction. |
format |
Other/Unknown Material |
author |
Velluva, Akhil Le Duc, Diana Cassatt-Johnstone, Molly Olsen, Remi-Andre Baleka, Sina Lin, Chen-Ching R. Lemke, Johannes R. Southon, John Burdin, Alexander Wang, Ming-Shan Grunewald, Sonja Rosendahl, Wilfried Joger, Ulrich Rutschmann, Sereina B. Hildebrandt, Thomas Fritsch, Guido A. Estes, James Kelso, Janet Dalén, Love Hofreiter, Michael Shapiro, Beth Schöneberg, Torsten |
spellingShingle |
Velluva, Akhil Le Duc, Diana Cassatt-Johnstone, Molly Olsen, Remi-Andre Baleka, Sina Lin, Chen-Ching R. Lemke, Johannes R. Southon, John Burdin, Alexander Wang, Ming-Shan Grunewald, Sonja Rosendahl, Wilfried Joger, Ulrich Rutschmann, Sereina B. Hildebrandt, Thomas Fritsch, Guido A. Estes, James Kelso, Janet Dalén, Love Hofreiter, Michael Shapiro, Beth Schöneberg, Torsten Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow |
author_facet |
Velluva, Akhil Le Duc, Diana Cassatt-Johnstone, Molly Olsen, Remi-Andre Baleka, Sina Lin, Chen-Ching R. Lemke, Johannes R. Southon, John Burdin, Alexander Wang, Ming-Shan Grunewald, Sonja Rosendahl, Wilfried Joger, Ulrich Rutschmann, Sereina B. Hildebrandt, Thomas Fritsch, Guido A. Estes, James Kelso, Janet Dalén, Love Hofreiter, Michael Shapiro, Beth Schöneberg, Torsten |
author_sort |
Velluva, Akhil |
title |
Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow |
title_short |
Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow |
title_full |
Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow |
title_fullStr |
Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow |
title_full_unstemmed |
Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow |
title_sort |
genomic basis for skin phenotype and cold adaptation in the extinct steller's sea cow |
publisher |
Zenodo |
publishDate |
2021 |
url |
https://doi.org/10.5281/zenodo.5665275 |
genre |
Steller's sea cow |
genre_facet |
Steller's sea cow |
op_relation |
https://doi.org/10.5061/dryad.cc2fqz673 https://zenodo.org/communities/dryad https://doi.org/10.5281/zenodo.5665274 https://doi.org/10.5281/zenodo.5665275 oai:zenodo.org:5665275 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode |
op_doi |
https://doi.org/10.5281/zenodo.566527510.5061/dryad.cc2fqz67310.5281/zenodo.5665274 |
_version_ |
1810482067541065728 |