The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus)
Background: Breast cancer chemotherapy with standard drugs such as doxorubicin will induce cardiotoxicity. Therefore, this study aims to evaluate the anticancer activity of C. odorata leaves extract in DMBA induced breast cancer on rats. Methods: Seven groups of Rattus novergicus were used: Four tre...
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Bulgarian Pharmaceutical Scientific Society
2021
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Online Access: | https://zenodo.org/record/5034060 https://doi.org/10.3897/pharmacia.68.e63956 |
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ftzenodo:oai:zenodo.org:5034060 2023-06-06T11:58:48+02:00 The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus) Yusuf, Hanifah Kamarlis, Reno Keumalazia Yusni, Yusni Fahriani, Marhami 2021-06-18 https://zenodo.org/record/5034060 https://doi.org/10.3897/pharmacia.68.e63956 unknown Bulgarian Pharmaceutical Scientific Society doi:10.3897/pharmacia.68.e63956.figure1 doi:10.3897/pharmacia.68.e63956.figure2 doi:10.3897/pharmacia.68.e63956.figure5 doi:10.3897/pharmacia.68.e63956.figure3 doi:10.3897/pharmacia.68.e63956.figure4 doi:10.3897/pharmacia.68.e63956.suppl1 https://zenodo.org/record/5034060 https://doi.org/10.3897/pharmacia.68.e63956 oai:zenodo.org:5034060 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode Pharmacia 68((2)) 493-499 Biota Plantae Tracheophyta Magnoliopsida Asterales Asteraceae Asteroideae Chromolaena Chromolaena odorata Animalia Chordata Mammalia Theria Eutheria Rodentia Myomorpha Muroidea Muridae Murinae Rattus Rattus norvegicus breast cancer DMBA doxorubicin info:eu-repo/semantics/article publication-article 2021 ftzenodo https://doi.org/10.3897/pharmacia.68.e6395610.3897/pharmacia.68.e63956.figure110.3897/pharmacia.68.e63956.figure210.3897/pharmacia.68.e63956.figure510.3897/pharmacia.68.e63956.figure310.3897/pharmacia.68.e63956.figure410.3897/pharmacia.68.e63956.suppl1 2023-04-13T21:43:18Z Background: Breast cancer chemotherapy with standard drugs such as doxorubicin will induce cardiotoxicity. Therefore, this study aims to evaluate the anticancer activity of C. odorata leaves extract in DMBA induced breast cancer on rats. Methods: Seven groups of Rattus novergicus were used: Four treatment groups of C. odorata extract (500, 1000, 2000, and 4000 mg/kg BW), normal control, breast cancer control, and doxorubicin treatment group. The number, volume, and weight of the nodule and the rats' body weight were compared among groups. Data was analyzed using paired t-test or one-way ANOVA with post hoc analysis as appropriate. Results: Significant decline of the number, volume, and weight of cancer nodules was observed in the treatment group (p < 0.001). The weight of the cancer nodule at week 16th was also significantly reduced in GCo2000 compared to Gdoxo (p < 0.0001). A significant increase in body weight was also dose-dependent, especially at week 11th (p < 0.05 in all comparisons) and week 16th (p < 0.001 in all comparisons). Conclusion: This study suggested that the ethanol extract of C. odorata leaves has anticancer and antiproliferative activity. Article in Journal/Newspaper Rattus rattus Zenodo Pharmacia 68 2 493 499 |
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topic |
Biota Plantae Tracheophyta Magnoliopsida Asterales Asteraceae Asteroideae Chromolaena Chromolaena odorata Animalia Chordata Mammalia Theria Eutheria Rodentia Myomorpha Muroidea Muridae Murinae Rattus Rattus norvegicus breast cancer DMBA doxorubicin |
spellingShingle |
Biota Plantae Tracheophyta Magnoliopsida Asterales Asteraceae Asteroideae Chromolaena Chromolaena odorata Animalia Chordata Mammalia Theria Eutheria Rodentia Myomorpha Muroidea Muridae Murinae Rattus Rattus norvegicus breast cancer DMBA doxorubicin Yusuf, Hanifah Kamarlis, Reno Keumalazia Yusni, Yusni Fahriani, Marhami The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus) |
topic_facet |
Biota Plantae Tracheophyta Magnoliopsida Asterales Asteraceae Asteroideae Chromolaena Chromolaena odorata Animalia Chordata Mammalia Theria Eutheria Rodentia Myomorpha Muroidea Muridae Murinae Rattus Rattus norvegicus breast cancer DMBA doxorubicin |
description |
Background: Breast cancer chemotherapy with standard drugs such as doxorubicin will induce cardiotoxicity. Therefore, this study aims to evaluate the anticancer activity of C. odorata leaves extract in DMBA induced breast cancer on rats. Methods: Seven groups of Rattus novergicus were used: Four treatment groups of C. odorata extract (500, 1000, 2000, and 4000 mg/kg BW), normal control, breast cancer control, and doxorubicin treatment group. The number, volume, and weight of the nodule and the rats' body weight were compared among groups. Data was analyzed using paired t-test or one-way ANOVA with post hoc analysis as appropriate. Results: Significant decline of the number, volume, and weight of cancer nodules was observed in the treatment group (p < 0.001). The weight of the cancer nodule at week 16th was also significantly reduced in GCo2000 compared to Gdoxo (p < 0.0001). A significant increase in body weight was also dose-dependent, especially at week 11th (p < 0.05 in all comparisons) and week 16th (p < 0.001 in all comparisons). Conclusion: This study suggested that the ethanol extract of C. odorata leaves has anticancer and antiproliferative activity. |
format |
Article in Journal/Newspaper |
author |
Yusuf, Hanifah Kamarlis, Reno Keumalazia Yusni, Yusni Fahriani, Marhami |
author_facet |
Yusuf, Hanifah Kamarlis, Reno Keumalazia Yusni, Yusni Fahriani, Marhami |
author_sort |
Yusuf, Hanifah |
title |
The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus) |
title_short |
The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus) |
title_full |
The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus) |
title_fullStr |
The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus) |
title_full_unstemmed |
The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus) |
title_sort |
anticancer activity of ethanol extract of chromolaena odorata leaves in 7,12-dimethylbenz[a]anthracene in (dmba) induced breast cancer wistar rats (rattus novergicus) |
publisher |
Bulgarian Pharmaceutical Scientific Society |
publishDate |
2021 |
url |
https://zenodo.org/record/5034060 https://doi.org/10.3897/pharmacia.68.e63956 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Pharmacia 68((2)) 493-499 |
op_relation |
doi:10.3897/pharmacia.68.e63956.figure1 doi:10.3897/pharmacia.68.e63956.figure2 doi:10.3897/pharmacia.68.e63956.figure5 doi:10.3897/pharmacia.68.e63956.figure3 doi:10.3897/pharmacia.68.e63956.figure4 doi:10.3897/pharmacia.68.e63956.suppl1 https://zenodo.org/record/5034060 https://doi.org/10.3897/pharmacia.68.e63956 oai:zenodo.org:5034060 |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode |
op_doi |
https://doi.org/10.3897/pharmacia.68.e6395610.3897/pharmacia.68.e63956.figure110.3897/pharmacia.68.e63956.figure210.3897/pharmacia.68.e63956.figure510.3897/pharmacia.68.e63956.figure310.3897/pharmacia.68.e63956.figure410.3897/pharmacia.68.e63956.suppl1 |
container_title |
Pharmacia |
container_volume |
68 |
container_issue |
2 |
container_start_page |
493 |
op_container_end_page |
499 |
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