Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds
Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated hemoglobin (HbA1c) are two major biomarkers of glycaemia where serum concentrations reflect glucose turnover...
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ftzenodo:oai:zenodo.org:4995867 2023-06-06T11:52:42+02:00 Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds Forsberg, Simon K. G. Kierczak, Marcin Ljungvall, Ingrid Merveille, Anne-Christine Gouni, Vassiliki Wiberg, Maria Willesen, Jakob Lundgren Hanås, Sofia Lequarré, Anne-Sophie Sørensen, Louise Mejer Tiret, Laurent McEntee, Kathleen Seppälä, Eija Koch, Jørgen Battaille, Géraldine Lohi, Hannes Fredholm, Merete Chetboul, Valerie Häggström, Jens Carlborg, Örjan Lindblad-Toh, Kerstin Höglund, Katja 2016-04-28 https://zenodo.org/record/4995867 https://doi.org/10.5061/dryad.ft6fv unknown doi:10.1371/journal.pone.0123173 https://zenodo.org/communities/dryad https://zenodo.org/record/4995867 https://doi.org/10.5061/dryad.ft6fv oai:zenodo.org:4995867 info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode breed specific sweep epistasis Canis lupus familiaris fructosamine gene-gene interaction diabetes Belgian shepherd breed info:eu-repo/semantics/other dataset 2016 ftzenodo https://doi.org/10.5061/dryad.ft6fv10.1371/journal.pone.0123173 2023-04-13T21:27:13Z Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated hemoglobin (HbA1c) are two major biomarkers of glycaemia where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on CFA 3 (pcorrected ≈ 1.68 × 10−6) in Belgian shepherd dogs. The associated region and its close neighborhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed specificity, we screened the genome for reduced heterozygosity stretches private to the Belgian shepherd breed. This revealed a region with reduced heterozygosity that shows a statistically significant interaction (p = 0.025) with the association region on CFA3. This region also harbours some interesting candidate genes and regulatory regions but the exact mechanisms underlying the interaction are still unknown. Nevertheless, this finding provides a plausible explanation for breed-specific genetic effects for complex traits in dogs. Shepherd breeds are at low risk of developing diabetes mellitus. The findings in Belgian shepherds could be connected to a protective mechanism against the disease. Further insight into the regulation of glucose metabolism could improve diagnostic and therapeutic methods for diabetes mellitus. Forsberg et al. Fructosamine dataForsberg_et_al_fructosamine_data.zip Dataset Canis lupus Zenodo |
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unknown |
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breed specific sweep epistasis Canis lupus familiaris fructosamine gene-gene interaction diabetes Belgian shepherd breed |
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breed specific sweep epistasis Canis lupus familiaris fructosamine gene-gene interaction diabetes Belgian shepherd breed Forsberg, Simon K. G. Kierczak, Marcin Ljungvall, Ingrid Merveille, Anne-Christine Gouni, Vassiliki Wiberg, Maria Willesen, Jakob Lundgren Hanås, Sofia Lequarré, Anne-Sophie Sørensen, Louise Mejer Tiret, Laurent McEntee, Kathleen Seppälä, Eija Koch, Jørgen Battaille, Géraldine Lohi, Hannes Fredholm, Merete Chetboul, Valerie Häggström, Jens Carlborg, Örjan Lindblad-Toh, Kerstin Höglund, Katja Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
topic_facet |
breed specific sweep epistasis Canis lupus familiaris fructosamine gene-gene interaction diabetes Belgian shepherd breed |
description |
Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated hemoglobin (HbA1c) are two major biomarkers of glycaemia where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on CFA 3 (pcorrected ≈ 1.68 × 10−6) in Belgian shepherd dogs. The associated region and its close neighborhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed specificity, we screened the genome for reduced heterozygosity stretches private to the Belgian shepherd breed. This revealed a region with reduced heterozygosity that shows a statistically significant interaction (p = 0.025) with the association region on CFA3. This region also harbours some interesting candidate genes and regulatory regions but the exact mechanisms underlying the interaction are still unknown. Nevertheless, this finding provides a plausible explanation for breed-specific genetic effects for complex traits in dogs. Shepherd breeds are at low risk of developing diabetes mellitus. The findings in Belgian shepherds could be connected to a protective mechanism against the disease. Further insight into the regulation of glucose metabolism could improve diagnostic and therapeutic methods for diabetes mellitus. Forsberg et al. Fructosamine dataForsberg_et_al_fructosamine_data.zip |
format |
Dataset |
author |
Forsberg, Simon K. G. Kierczak, Marcin Ljungvall, Ingrid Merveille, Anne-Christine Gouni, Vassiliki Wiberg, Maria Willesen, Jakob Lundgren Hanås, Sofia Lequarré, Anne-Sophie Sørensen, Louise Mejer Tiret, Laurent McEntee, Kathleen Seppälä, Eija Koch, Jørgen Battaille, Géraldine Lohi, Hannes Fredholm, Merete Chetboul, Valerie Häggström, Jens Carlborg, Örjan Lindblad-Toh, Kerstin Höglund, Katja |
author_facet |
Forsberg, Simon K. G. Kierczak, Marcin Ljungvall, Ingrid Merveille, Anne-Christine Gouni, Vassiliki Wiberg, Maria Willesen, Jakob Lundgren Hanås, Sofia Lequarré, Anne-Sophie Sørensen, Louise Mejer Tiret, Laurent McEntee, Kathleen Seppälä, Eija Koch, Jørgen Battaille, Géraldine Lohi, Hannes Fredholm, Merete Chetboul, Valerie Häggström, Jens Carlborg, Örjan Lindblad-Toh, Kerstin Höglund, Katja |
author_sort |
Forsberg, Simon K. G. |
title |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_short |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_full |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_fullStr |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_full_unstemmed |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_sort |
data from: the shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in belgian shepherds |
publishDate |
2016 |
url |
https://zenodo.org/record/4995867 https://doi.org/10.5061/dryad.ft6fv |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
doi:10.1371/journal.pone.0123173 https://zenodo.org/communities/dryad https://zenodo.org/record/4995867 https://doi.org/10.5061/dryad.ft6fv oai:zenodo.org:4995867 |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.ft6fv10.1371/journal.pone.0123173 |
_version_ |
1767958698566615040 |