Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon
Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens, and shift in dietary lipid availability. Ma...
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ftzenodo:oai:zenodo.org:4975824 2023-05-15T15:30:23+02:00 Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen Sandve, Simen R. 2017-12-14 https://zenodo.org/record/4975824 https://doi.org/10.5061/dryad.j4h65 unknown doi:10.1111/mec.14533 https://zenodo.org/communities/dryad https://zenodo.org/record/4975824 https://doi.org/10.5061/dryad.j4h65 oai:zenodo.org:4975824 info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode life-stage Salmo salar info:eu-repo/semantics/other dataset 2017 ftzenodo https://doi.org/10.5061/dryad.j4h6510.1111/mec.14533 2023-03-10T14:28:54Z Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens, and shift in dietary lipid availability. Many anticipatory changes in physiology occur before migration to sea, but little is known about the molecular nature of these changes. Here we use a long term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh- and saltwater. We find that lipid metabolism is highly plastic in response to differences in dietary lipid composition in freshwater, but then undergoes a marked shift when salmon transitions to the marine life-stage. Expression of genes in liver relating to lipogenesis and lipid transport decrease overall and become less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid specific whole-genome duplication on lipid metabolism reveals several pathways with significantly different (p<0.05) duplicate retention or duplicate regulatory conservation. We also find a limited number of cases where the whole genome duplication has resulted in an increased gene dosage. Our results demonstrate the presence of a life-stage associated remodeling of lipid metabolism at the gene regulatory level, suggesting an evolved preparatory optimization of lipid metabolism Supplementary_files_Harvey_et_al_MEC-17-0821This zip file contains 10 supplementary files associated to Harvey et al. "Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon". Dataset Atlantic salmon Salmo salar Zenodo |
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unknown |
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life-stage Salmo salar |
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life-stage Salmo salar Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen Sandve, Simen R. Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
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life-stage Salmo salar |
description |
Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens, and shift in dietary lipid availability. Many anticipatory changes in physiology occur before migration to sea, but little is known about the molecular nature of these changes. Here we use a long term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh- and saltwater. We find that lipid metabolism is highly plastic in response to differences in dietary lipid composition in freshwater, but then undergoes a marked shift when salmon transitions to the marine life-stage. Expression of genes in liver relating to lipogenesis and lipid transport decrease overall and become less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid specific whole-genome duplication on lipid metabolism reveals several pathways with significantly different (p<0.05) duplicate retention or duplicate regulatory conservation. We also find a limited number of cases where the whole genome duplication has resulted in an increased gene dosage. Our results demonstrate the presence of a life-stage associated remodeling of lipid metabolism at the gene regulatory level, suggesting an evolved preparatory optimization of lipid metabolism Supplementary_files_Harvey_et_al_MEC-17-0821This zip file contains 10 supplementary files associated to Harvey et al. "Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon". |
format |
Dataset |
author |
Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen Sandve, Simen R. |
author_facet |
Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen Sandve, Simen R. |
author_sort |
Gillard, Gareth |
title |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_short |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_full |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_fullStr |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_full_unstemmed |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_sort |
data from: life-stage associated remodeling of lipid metabolism regulation in atlantic salmon |
publishDate |
2017 |
url |
https://zenodo.org/record/4975824 https://doi.org/10.5061/dryad.j4h65 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
doi:10.1111/mec.14533 https://zenodo.org/communities/dryad https://zenodo.org/record/4975824 https://doi.org/10.5061/dryad.j4h65 oai:zenodo.org:4975824 |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.j4h6510.1111/mec.14533 |
_version_ |
1766360831896846336 |