Data from: Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon
Males and females share many traits that have a common genetic basis; however, selection on these traits often differs between the sexes, leading to sexual conflict. Under such sexual antagonism, theory predicts the evolution of genetic architectures that resolve this sexual conflict. Yet, despite i...
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ftzenodo:oai:zenodo.org:4970219 2024-09-15T17:56:34+00:00 Data from: Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon Barson, Nicola J. Aykanat, Tuku Hindar, Kjetil Baranski, Matthew Bolstad, Geir H. Fiske, Peder Jacq, Céleste Jensen, Arne J. Johnston, Susan E. Karlsson, Sten Kent, Matthew Moen, Thomas Niemelä, Eero Nome, Torfinn Næsje, Tor F. Orell, Panu Romakkaniemi, Atso Sægrov, Harald Urdal, Kurt Erkinaro, Jaakko Lien, Sigbjørn Primmer, Craig R. 2015-11-05 https://doi.org/10.5061/dryad.23h4q unknown Zenodo https://doi.org/10.1038/nature16062 https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.23h4q oai:zenodo.org:4970219 info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode Salmo salar evolutionary genetics info:eu-repo/semantics/other 2015 ftzenodo https://doi.org/10.5061/dryad.23h4q10.1038/nature16062 2024-07-26T18:57:43Z Males and females share many traits that have a common genetic basis; however, selection on these traits often differs between the sexes, leading to sexual conflict. Under such sexual antagonism, theory predicts the evolution of genetic architectures that resolve this sexual conflict. Yet, despite intense theoretical and empirical interest, the specific loci underlying sexually antagonistic phenotypes have rarely been identified, limiting our understanding of how sexual conflict impacts genome evolution and the maintenance of genetic diversity. Here we identify a large effect locus controlling age at maturity in Atlantic salmon (Salmo salar), an important fitness trait in which selection favours earlier maturation in males than females and show it is a clear example of sex-dependent dominance that reduces intralocus sexual conflict and maintains adaptive variation in wild populations. Using high-density single nucleotide polymorphism data across 57 wild populations and whole genome re-sequencing, we find that the vestigial-like family member 3 gene (VGLL3) exhibits sex-dependent dominance in salmon, promoting earlier and later maturation in males and females, respectively. VGLL3, an adiposity regulator associated with size and age at maturity in humans, explained 39% of phenotypic variation, an unexpectedly large proportion for what is usually considered a highly polygenic trait. Such large effects are predicted under balancing selection from either sexually antagonistic or spatially varying selection. Our results provide the first empirical example of dominance reversal allowing greater optimization of phenotypes within each sex, contributing to the resolution of sexual conflict in a major and widespread evolutionary trade-off between age and size at maturity. They also provide key empirical evidence for how variation in reproductive strategies can be maintained over large geographical scales. We anticipate these findings will have a substantial impact on population management in a range of harvested species ... Other/Unknown Material Atlantic salmon Salmo salar Zenodo |
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Salmo salar evolutionary genetics |
spellingShingle |
Salmo salar evolutionary genetics Barson, Nicola J. Aykanat, Tuku Hindar, Kjetil Baranski, Matthew Bolstad, Geir H. Fiske, Peder Jacq, Céleste Jensen, Arne J. Johnston, Susan E. Karlsson, Sten Kent, Matthew Moen, Thomas Niemelä, Eero Nome, Torfinn Næsje, Tor F. Orell, Panu Romakkaniemi, Atso Sægrov, Harald Urdal, Kurt Erkinaro, Jaakko Lien, Sigbjørn Primmer, Craig R. Data from: Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon |
topic_facet |
Salmo salar evolutionary genetics |
description |
Males and females share many traits that have a common genetic basis; however, selection on these traits often differs between the sexes, leading to sexual conflict. Under such sexual antagonism, theory predicts the evolution of genetic architectures that resolve this sexual conflict. Yet, despite intense theoretical and empirical interest, the specific loci underlying sexually antagonistic phenotypes have rarely been identified, limiting our understanding of how sexual conflict impacts genome evolution and the maintenance of genetic diversity. Here we identify a large effect locus controlling age at maturity in Atlantic salmon (Salmo salar), an important fitness trait in which selection favours earlier maturation in males than females and show it is a clear example of sex-dependent dominance that reduces intralocus sexual conflict and maintains adaptive variation in wild populations. Using high-density single nucleotide polymorphism data across 57 wild populations and whole genome re-sequencing, we find that the vestigial-like family member 3 gene (VGLL3) exhibits sex-dependent dominance in salmon, promoting earlier and later maturation in males and females, respectively. VGLL3, an adiposity regulator associated with size and age at maturity in humans, explained 39% of phenotypic variation, an unexpectedly large proportion for what is usually considered a highly polygenic trait. Such large effects are predicted under balancing selection from either sexually antagonistic or spatially varying selection. Our results provide the first empirical example of dominance reversal allowing greater optimization of phenotypes within each sex, contributing to the resolution of sexual conflict in a major and widespread evolutionary trade-off between age and size at maturity. They also provide key empirical evidence for how variation in reproductive strategies can be maintained over large geographical scales. We anticipate these findings will have a substantial impact on population management in a range of harvested species ... |
format |
Other/Unknown Material |
author |
Barson, Nicola J. Aykanat, Tuku Hindar, Kjetil Baranski, Matthew Bolstad, Geir H. Fiske, Peder Jacq, Céleste Jensen, Arne J. Johnston, Susan E. Karlsson, Sten Kent, Matthew Moen, Thomas Niemelä, Eero Nome, Torfinn Næsje, Tor F. Orell, Panu Romakkaniemi, Atso Sægrov, Harald Urdal, Kurt Erkinaro, Jaakko Lien, Sigbjørn Primmer, Craig R. |
author_facet |
Barson, Nicola J. Aykanat, Tuku Hindar, Kjetil Baranski, Matthew Bolstad, Geir H. Fiske, Peder Jacq, Céleste Jensen, Arne J. Johnston, Susan E. Karlsson, Sten Kent, Matthew Moen, Thomas Niemelä, Eero Nome, Torfinn Næsje, Tor F. Orell, Panu Romakkaniemi, Atso Sægrov, Harald Urdal, Kurt Erkinaro, Jaakko Lien, Sigbjørn Primmer, Craig R. |
author_sort |
Barson, Nicola J. |
title |
Data from: Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon |
title_short |
Data from: Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon |
title_full |
Data from: Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon |
title_fullStr |
Data from: Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon |
title_full_unstemmed |
Data from: Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon |
title_sort |
data from: sex-dependent dominance at a single locus maintains variation in age at maturity in salmon |
publisher |
Zenodo |
publishDate |
2015 |
url |
https://doi.org/10.5061/dryad.23h4q |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
https://doi.org/10.1038/nature16062 https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.23h4q oai:zenodo.org:4970219 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.23h4q10.1038/nature16062 |
_version_ |
1810432766282563584 |