Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird
Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is...
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ftzenodo:oai:zenodo.org:4944535 2023-06-06T11:59:41+02:00 Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird Bauch, Christina Becker, Peter H. Verhulst, Simon 2013-12-09 https://zenodo.org/record/4944535 https://doi.org/10.5061/dryad.k8r75 unknown doi:10.1111/mec.12602 https://zenodo.org/communities/dryad https://zenodo.org/record/4944535 https://doi.org/10.5061/dryad.k8r75 oai:zenodo.org:4944535 info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode selective disappearance life-history lifestyle Sterna hirundo info:eu-repo/semantics/other dataset 2013 ftzenodo https://doi.org/10.5061/dryad.k8r7510.1111/mec.12602 2023-04-13T21:22:02Z Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is not known. We measured telomeres in erythrocytes of wild common terns Sterna hirundo using terminal restriction fragment analysis. This yields a distribution of telomere lengths for each sample, and we investigated how different telomere subpopulations (percentiles) varied in their relation to age and fitness proxies. Longer telomeres within a genome lost more base pairs with age and were better predictors of survival than shorter telomeres. Likewise, fitness proxies such as arrival date at the breeding grounds and reproductive success were best predicted by telomere length at the higher percentiles. Our finding that longer telomeres within a genome predict fitness components better than the shorter telomeres indicates that they are a more informative ageing biomarker. This finding contrasts with the fact that cell senescence is triggered by the shortest telomeres. We suggest that this paradox arises, because longer telomeres lose more base pairs per unit time and thus better reflect the various forms of stress that accelerate telomere shortening, and that telomeres primarily function as biomarker because their shortening reflects cumulative effects of various stressors rather than reflecting telomere-induced cell senescence. BauchBeckerVerhulst_MolEcol_Long-telomeres-better-predict-fitness-proxiesData Dataset Sterna hirundo Zenodo |
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unknown |
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selective disappearance life-history lifestyle Sterna hirundo |
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selective disappearance life-history lifestyle Sterna hirundo Bauch, Christina Becker, Peter H. Verhulst, Simon Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
topic_facet |
selective disappearance life-history lifestyle Sterna hirundo |
description |
Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is not known. We measured telomeres in erythrocytes of wild common terns Sterna hirundo using terminal restriction fragment analysis. This yields a distribution of telomere lengths for each sample, and we investigated how different telomere subpopulations (percentiles) varied in their relation to age and fitness proxies. Longer telomeres within a genome lost more base pairs with age and were better predictors of survival than shorter telomeres. Likewise, fitness proxies such as arrival date at the breeding grounds and reproductive success were best predicted by telomere length at the higher percentiles. Our finding that longer telomeres within a genome predict fitness components better than the shorter telomeres indicates that they are a more informative ageing biomarker. This finding contrasts with the fact that cell senescence is triggered by the shortest telomeres. We suggest that this paradox arises, because longer telomeres lose more base pairs per unit time and thus better reflect the various forms of stress that accelerate telomere shortening, and that telomeres primarily function as biomarker because their shortening reflects cumulative effects of various stressors rather than reflecting telomere-induced cell senescence. BauchBeckerVerhulst_MolEcol_Long-telomeres-better-predict-fitness-proxiesData |
format |
Dataset |
author |
Bauch, Christina Becker, Peter H. Verhulst, Simon |
author_facet |
Bauch, Christina Becker, Peter H. Verhulst, Simon |
author_sort |
Bauch, Christina |
title |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_short |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_full |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_fullStr |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_full_unstemmed |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_sort |
data from: within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
publishDate |
2013 |
url |
https://zenodo.org/record/4944535 https://doi.org/10.5061/dryad.k8r75 |
genre |
Sterna hirundo |
genre_facet |
Sterna hirundo |
op_relation |
doi:10.1111/mec.12602 https://zenodo.org/communities/dryad https://zenodo.org/record/4944535 https://doi.org/10.5061/dryad.k8r75 oai:zenodo.org:4944535 |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.k8r7510.1111/mec.12602 |
_version_ |
1767949846587637760 |