Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas
The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas....
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ftzenodo:oai:zenodo.org:4937559 2024-09-15T18:03:04+00:00 Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng 2017-12-06 https://doi.org/10.5061/dryad.7d6c5 unknown Zenodo https://doi.org/10.1098/rsob.160289 https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.7d6c5 oai:zenodo.org:4937559 info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode Circulating haemocyte Membrane receptor Immune regulation Crassostrea gigas Neuroendocrine immunomodulatory axis info:eu-repo/semantics/other 2017 ftzenodo https://doi.org/10.5061/dryad.7d6c510.1098/rsob.160289 2024-07-26T16:45:44Z The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the 'nervous-haemocyte' NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. Figure and Table Figures & Tables Other/Unknown Material Crassostrea gigas Pacific oyster Zenodo |
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Circulating haemocyte Membrane receptor Immune regulation Crassostrea gigas Neuroendocrine immunomodulatory axis |
spellingShingle |
Circulating haemocyte Membrane receptor Immune regulation Crassostrea gigas Neuroendocrine immunomodulatory axis Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
topic_facet |
Circulating haemocyte Membrane receptor Immune regulation Crassostrea gigas Neuroendocrine immunomodulatory axis |
description |
The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the 'nervous-haemocyte' NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. Figure and Table Figures & Tables |
format |
Other/Unknown Material |
author |
Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng |
author_facet |
Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng |
author_sort |
Liu, Zhaoqun |
title |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_short |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_full |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_fullStr |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_full_unstemmed |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_sort |
data from: the neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster crassostrea gigas |
publisher |
Zenodo |
publishDate |
2017 |
url |
https://doi.org/10.5061/dryad.7d6c5 |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
https://doi.org/10.1098/rsob.160289 https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.7d6c5 oai:zenodo.org:4937559 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.7d6c510.1098/rsob.160289 |
_version_ |
1810440592813981696 |