Genomic and fitness consequences of inbreeding in an endangered carnivore
Reduced fitness through genetic drift and inbreeding is a major threat to small and isolated populations. Although previous studies have generally used genetically verified pedigrees to document effects of inbreeding and gene flow, these often fail to capture the whole inbreeding history of the spec...
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ftzenodo:oai:zenodo.org:4748272 2023-05-15T14:31:10+02:00 Genomic and fitness consequences of inbreeding in an endangered carnivore Hasselgren, Malin Dussex, Nicolas von Seth, Johanna Angerbjörn, Anders Olsen, Remi-André Dalén, Love Noren, Karin 2021-05-10 https://zenodo.org/record/4748272 https://doi.org/10.5061/dryad.gmsbcc2mn unknown https://zenodo.org/communities/dryad https://zenodo.org/record/4748272 https://doi.org/10.5061/dryad.gmsbcc2mn oai:zenodo.org:4748272 info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode inbreeding depression genetic rescue Small population ROH info:eu-repo/semantics/other dataset 2021 ftzenodo https://doi.org/10.5061/dryad.gmsbcc2mn 2023-03-10T17:47:34Z Reduced fitness through genetic drift and inbreeding is a major threat to small and isolated populations. Although previous studies have generally used genetically verified pedigrees to document effects of inbreeding and gene flow, these often fail to capture the whole inbreeding history of the species. By assembling a draft arctic fox (Vulpes lagopus) genome and re-sequencing complete genomes of 23 additional foxes born before and after a well-documented immigration event in Scandinavia, we here look into the genomic consequences of inbreeding and genetic rescue. We found a difference in genome-wide diversity, with 18% higher heterozygosity and 81% lower FROH in immigrant F1 compared to native individuals. However, more distant descendants of immigrants (F2, F3) did not show the same pattern. We also found that foxes with lower inbreeding had higher probability to survive their first year of life. Our results demonstrate the important link between genetic variation and fitness as well as the transient nature of genetic rescue. Moreover, our results have implications in conservation biology as they demonstrate that inbreeding depression can effectively be detected in the wild by a genomic approach. Dataset Arctic Fox Arctic Vulpes lagopus Zenodo Arctic |
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Open Polar |
collection |
Zenodo |
op_collection_id |
ftzenodo |
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unknown |
topic |
inbreeding depression genetic rescue Small population ROH |
spellingShingle |
inbreeding depression genetic rescue Small population ROH Hasselgren, Malin Dussex, Nicolas von Seth, Johanna Angerbjörn, Anders Olsen, Remi-André Dalén, Love Noren, Karin Genomic and fitness consequences of inbreeding in an endangered carnivore |
topic_facet |
inbreeding depression genetic rescue Small population ROH |
description |
Reduced fitness through genetic drift and inbreeding is a major threat to small and isolated populations. Although previous studies have generally used genetically verified pedigrees to document effects of inbreeding and gene flow, these often fail to capture the whole inbreeding history of the species. By assembling a draft arctic fox (Vulpes lagopus) genome and re-sequencing complete genomes of 23 additional foxes born before and after a well-documented immigration event in Scandinavia, we here look into the genomic consequences of inbreeding and genetic rescue. We found a difference in genome-wide diversity, with 18% higher heterozygosity and 81% lower FROH in immigrant F1 compared to native individuals. However, more distant descendants of immigrants (F2, F3) did not show the same pattern. We also found that foxes with lower inbreeding had higher probability to survive their first year of life. Our results demonstrate the important link between genetic variation and fitness as well as the transient nature of genetic rescue. Moreover, our results have implications in conservation biology as they demonstrate that inbreeding depression can effectively be detected in the wild by a genomic approach. |
format |
Dataset |
author |
Hasselgren, Malin Dussex, Nicolas von Seth, Johanna Angerbjörn, Anders Olsen, Remi-André Dalén, Love Noren, Karin |
author_facet |
Hasselgren, Malin Dussex, Nicolas von Seth, Johanna Angerbjörn, Anders Olsen, Remi-André Dalén, Love Noren, Karin |
author_sort |
Hasselgren, Malin |
title |
Genomic and fitness consequences of inbreeding in an endangered carnivore |
title_short |
Genomic and fitness consequences of inbreeding in an endangered carnivore |
title_full |
Genomic and fitness consequences of inbreeding in an endangered carnivore |
title_fullStr |
Genomic and fitness consequences of inbreeding in an endangered carnivore |
title_full_unstemmed |
Genomic and fitness consequences of inbreeding in an endangered carnivore |
title_sort |
genomic and fitness consequences of inbreeding in an endangered carnivore |
publishDate |
2021 |
url |
https://zenodo.org/record/4748272 https://doi.org/10.5061/dryad.gmsbcc2mn |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Fox Arctic Vulpes lagopus |
genre_facet |
Arctic Fox Arctic Vulpes lagopus |
op_relation |
https://zenodo.org/communities/dryad https://zenodo.org/record/4748272 https://doi.org/10.5061/dryad.gmsbcc2mn oai:zenodo.org:4748272 |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.gmsbcc2mn |
_version_ |
1766304872701886464 |