Cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in Clione limacina central pattern generator swim interneurons
Typically, the marine mollusk, Clione limacina , exhibits a slow, hovering locomotor gait to maintain its position in the water column. However, the animal exhibits behaviorally relevant locomotor swim acceleration during escape response and feeding behavior. Both nitric oxide and serotonin mediate...
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ftzenodo:oai:zenodo.org:4552896 2024-09-15T18:02:39+00:00 Cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in Clione limacina central pattern generator swim interneurons Pirtle, Thomas Satterlie, Richard 2021-02-19 https://doi.org/10.5061/dryad.3xsj3txdc unknown Zenodo https://doi.org/10.1152/jn.2000.83.4.2163 https://doi.org/10.1093/iob/obaa045 https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.3xsj3txdc oai:zenodo.org:4552896 info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode cGMP Nitric Oxide serotonin Clione Central Pattern Generator info:eu-repo/semantics/other 2021 ftzenodo https://doi.org/10.5061/dryad.3xsj3txdc10.1152/jn.2000.83.4.216310.1093/iob/obaa045 2024-07-26T22:55:52Z Typically, the marine mollusk, Clione limacina , exhibits a slow, hovering locomotor gait to maintain its position in the water column. However, the animal exhibits behaviorally relevant locomotor swim acceleration during escape response and feeding behavior. Both nitric oxide and serotonin mediate this behavioral swim acceleration. In this study, we examine the role that the second messenger, cGMP, plays in mediating nitric oxide and serotonin induced swim acceleration. We observed that application of an analogue of cGMP or an activator of soluble guanylyl cyclase, increased fictive locomotor speed recorded from Pd-7 interneurons of the animal's locomotor central pattern generator. Moreover, inhibition of soluble guanylyl cyclase decreased fictive locomotor speed. These results suggest that basal levels of cGMP are important for slow swimming and that increased production of cGMP mediates swim acceleration in Clione . Because nitric oxide has its effect through cGMP signaling and because we show herein that cGMP produces cellular changes in Clione swim interneurons that are consistent to cellular changes produced by serotonin application, we hypothesize that both nitric oxide and serotonin function via a common signal transduction pathway that involves cGMP. Our results show that cGMP mediates nitric oxide-induced but not serotonin-induced swim acceleration in Clione . The following is a summary of the data set components. Supplement 1 Fig. 1 Effect of 8-Br-cGMP on Fictive Swim Frequency This Excel file summarizes the data showing how 8-Br-cGMP changes fictive swim frequency recorded from Pd-7 swim interneurons of the Clione swim central pattern generator. The first sheet summarizes all of the data used in this figure, including statistical results. Subsequent sheets show the individual data for these experiments. Supplement 2 Fig. 2 Effect of ODQ + NO on Fictive Swim Frequency This Excel file summarizes the data showing that ODQ, an inhibitor of soluble guanylyl cyclase, prevents nitric oxide from causing an ... Other/Unknown Material Clione limacina Zenodo |
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cGMP Nitric Oxide serotonin Clione Central Pattern Generator |
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cGMP Nitric Oxide serotonin Clione Central Pattern Generator Pirtle, Thomas Satterlie, Richard Cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in Clione limacina central pattern generator swim interneurons |
topic_facet |
cGMP Nitric Oxide serotonin Clione Central Pattern Generator |
description |
Typically, the marine mollusk, Clione limacina , exhibits a slow, hovering locomotor gait to maintain its position in the water column. However, the animal exhibits behaviorally relevant locomotor swim acceleration during escape response and feeding behavior. Both nitric oxide and serotonin mediate this behavioral swim acceleration. In this study, we examine the role that the second messenger, cGMP, plays in mediating nitric oxide and serotonin induced swim acceleration. We observed that application of an analogue of cGMP or an activator of soluble guanylyl cyclase, increased fictive locomotor speed recorded from Pd-7 interneurons of the animal's locomotor central pattern generator. Moreover, inhibition of soluble guanylyl cyclase decreased fictive locomotor speed. These results suggest that basal levels of cGMP are important for slow swimming and that increased production of cGMP mediates swim acceleration in Clione . Because nitric oxide has its effect through cGMP signaling and because we show herein that cGMP produces cellular changes in Clione swim interneurons that are consistent to cellular changes produced by serotonin application, we hypothesize that both nitric oxide and serotonin function via a common signal transduction pathway that involves cGMP. Our results show that cGMP mediates nitric oxide-induced but not serotonin-induced swim acceleration in Clione . The following is a summary of the data set components. Supplement 1 Fig. 1 Effect of 8-Br-cGMP on Fictive Swim Frequency This Excel file summarizes the data showing how 8-Br-cGMP changes fictive swim frequency recorded from Pd-7 swim interneurons of the Clione swim central pattern generator. The first sheet summarizes all of the data used in this figure, including statistical results. Subsequent sheets show the individual data for these experiments. Supplement 2 Fig. 2 Effect of ODQ + NO on Fictive Swim Frequency This Excel file summarizes the data showing that ODQ, an inhibitor of soluble guanylyl cyclase, prevents nitric oxide from causing an ... |
format |
Other/Unknown Material |
author |
Pirtle, Thomas Satterlie, Richard |
author_facet |
Pirtle, Thomas Satterlie, Richard |
author_sort |
Pirtle, Thomas |
title |
Cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in Clione limacina central pattern generator swim interneurons |
title_short |
Cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in Clione limacina central pattern generator swim interneurons |
title_full |
Cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in Clione limacina central pattern generator swim interneurons |
title_fullStr |
Cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in Clione limacina central pattern generator swim interneurons |
title_full_unstemmed |
Cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in Clione limacina central pattern generator swim interneurons |
title_sort |
cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in clione limacina central pattern generator swim interneurons |
publisher |
Zenodo |
publishDate |
2021 |
url |
https://doi.org/10.5061/dryad.3xsj3txdc |
genre |
Clione limacina |
genre_facet |
Clione limacina |
op_relation |
https://doi.org/10.1152/jn.2000.83.4.2163 https://doi.org/10.1093/iob/obaa045 https://zenodo.org/communities/dryad https://doi.org/10.5061/dryad.3xsj3txdc oai:zenodo.org:4552896 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode |
op_doi |
https://doi.org/10.5061/dryad.3xsj3txdc10.1152/jn.2000.83.4.216310.1093/iob/obaa045 |
_version_ |
1810440077304659968 |