Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products
ABSTRACT Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and novel bioactive compounds. In this revi...
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ftzenodo:oai:zenodo.org:4293886 2024-09-15T18:23:55+00:00 Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products Subramani, Ramesh Sipkema, Detmer 2019-04-26 https://doi.org/10.3390/md17050249 unknown Zenodo https://www.mdpi.com/1660-3397/17/5/249/htm https://zenodo.org/communities/sponges https://zenodo.org/communities/eu https://doi.org/10.3390/md17050249 oai:zenodo.org:4293886 info:eu-repo/semantics/openAccess Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode Marine Drugs, 17(5), 249, (2019-04-26) rare actinomycetes marine actinobacteri cultivation natural products bioactive compounds European Union (EU) Horizon 2020 Grant Agreement No 679849 Deep-sea Sponge Grounds Ecosystems of the North Atlantic: an integrated approach towards their preservation and sustainable exploitation SponGES info:eu-repo/semantics/article 2019 ftzenodo https://doi.org/10.3390/md17050249 2024-07-27T06:23:58Z ABSTRACT Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and novel bioactive compounds. In this review, we aim to summarize the present knowledge on the isolation, diversity, distribution and natural product discovery of marine rare actinomycetes reported from mid-2013 to 2017. A total of 97 new species, representing 9 novel genera and belonging to 27 families of marine rare actinomycetes have been reported, with the highest numbers of novel isolates from the families Pseudonocardiaceae, Demequinaceae, Micromonosporaceae and Nocardioidaceae. Additionally, this study reviewed 167 new bioactive compounds produced by 58 different rare actinomycete species representing 24 genera. Most of the compounds produced by the marine rare actinomycetes present antibacterial, antifungal, antiparasitic, anticancer or antimalarial activities. The highest numbers of natural products were derived from the genera Nocardiopsis , Micromonospora , Salinispora and Pseudonocardia . Members of the genus Micromonospora were revealed to be the richest source of chemically diverse and unique bioactive natural products. ACKNOWLEDGEMENTS We are thankful to Steven Sutcliffe, the University of the South Pacific for English proofreading of the manuscript. AUTHOR CONTRIBUTIONS R.S. conceived, designed the work and wrote the manuscript; D.S. conceived, critically analyzed the data, revised and corrected the manuscript. FUNDING D.S. acknowledges funding from the European Union's Horizon 2020 research and innovation program under Grant Agreement No. 679849 (SponGES). Article in Journal/Newspaper North Atlantic Zenodo Marine Drugs 17 5 249 |
institution |
Open Polar |
collection |
Zenodo |
op_collection_id |
ftzenodo |
language |
unknown |
topic |
rare actinomycetes marine actinobacteri cultivation natural products bioactive compounds European Union (EU) Horizon 2020 Grant Agreement No 679849 Deep-sea Sponge Grounds Ecosystems of the North Atlantic: an integrated approach towards their preservation and sustainable exploitation SponGES |
spellingShingle |
rare actinomycetes marine actinobacteri cultivation natural products bioactive compounds European Union (EU) Horizon 2020 Grant Agreement No 679849 Deep-sea Sponge Grounds Ecosystems of the North Atlantic: an integrated approach towards their preservation and sustainable exploitation SponGES Subramani, Ramesh Sipkema, Detmer Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
topic_facet |
rare actinomycetes marine actinobacteri cultivation natural products bioactive compounds European Union (EU) Horizon 2020 Grant Agreement No 679849 Deep-sea Sponge Grounds Ecosystems of the North Atlantic: an integrated approach towards their preservation and sustainable exploitation SponGES |
description |
ABSTRACT Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and novel bioactive compounds. In this review, we aim to summarize the present knowledge on the isolation, diversity, distribution and natural product discovery of marine rare actinomycetes reported from mid-2013 to 2017. A total of 97 new species, representing 9 novel genera and belonging to 27 families of marine rare actinomycetes have been reported, with the highest numbers of novel isolates from the families Pseudonocardiaceae, Demequinaceae, Micromonosporaceae and Nocardioidaceae. Additionally, this study reviewed 167 new bioactive compounds produced by 58 different rare actinomycete species representing 24 genera. Most of the compounds produced by the marine rare actinomycetes present antibacterial, antifungal, antiparasitic, anticancer or antimalarial activities. The highest numbers of natural products were derived from the genera Nocardiopsis , Micromonospora , Salinispora and Pseudonocardia . Members of the genus Micromonospora were revealed to be the richest source of chemically diverse and unique bioactive natural products. ACKNOWLEDGEMENTS We are thankful to Steven Sutcliffe, the University of the South Pacific for English proofreading of the manuscript. AUTHOR CONTRIBUTIONS R.S. conceived, designed the work and wrote the manuscript; D.S. conceived, critically analyzed the data, revised and corrected the manuscript. FUNDING D.S. acknowledges funding from the European Union's Horizon 2020 research and innovation program under Grant Agreement No. 679849 (SponGES). |
format |
Article in Journal/Newspaper |
author |
Subramani, Ramesh Sipkema, Detmer |
author_facet |
Subramani, Ramesh Sipkema, Detmer |
author_sort |
Subramani, Ramesh |
title |
Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
title_short |
Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
title_full |
Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
title_fullStr |
Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
title_full_unstemmed |
Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
title_sort |
marine rare actinomycetes: a promising source of structurally diverse and unique novel natural products |
publisher |
Zenodo |
publishDate |
2019 |
url |
https://doi.org/10.3390/md17050249 |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_source |
Marine Drugs, 17(5), 249, (2019-04-26) |
op_relation |
https://www.mdpi.com/1660-3397/17/5/249/htm https://zenodo.org/communities/sponges https://zenodo.org/communities/eu https://doi.org/10.3390/md17050249 oai:zenodo.org:4293886 |
op_rights |
info:eu-repo/semantics/openAccess Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode |
op_doi |
https://doi.org/10.3390/md17050249 |
container_title |
Marine Drugs |
container_volume |
17 |
container_issue |
5 |
container_start_page |
249 |
_version_ |
1810464207558148096 |