| Summary: | Background : On 31 January 2020, the United Kingdom (UK) formally left the European Union (EU). Only a short transition period, until 31 December 2020, is available to negotiate collaborations for research in biomedical sciences and health care. Within the European scientific community, two opinions are common: 1) Brexit is an opportunity to obtain more funding at the expense of the departing British; and 2) UK colleagues should continue to collaborate in EU scientific efforts, including Horizon Europe and Erasmus+. To provide evidence for more informed negotiations, we sought to determine the contribution of the UK to EU’s research in biomedical sciences. Methods : We performed a macro level scientometric analysis to estimate the contribution of the UK and EU member states, including those associated with EU-funding (EU+) namely Albania, Armenia, Bosnia-Herzegovina, Faroe Islands, Georgia, Iceland, Israel, Macedonia, Moldova, Montenegro, Norway, Serbia, Switzerland, Tunisia, Turkey, and Ukraine, to preclinical, clinical and health sciences. We searched the Web of Science database to count the total number of scientific publications and the top 1% most cited publications in the world between 2008 and 2017, calculated the performance efficiency by dividing the top 1% by the total number, and calculated the odds ratios to create a ranking of performance efficiency. We then compared the contribution of the UK to all the EU+ -based publications and the top 1% to the contributions of the ten EU member states with the largest biomedical research output and also compared the respective contributions to EU+ publications that resulted from collaborations with other regions in the world. Results : We found 2,991,016 biomedical publications from EU+ during 2008–2017, of which 19,019 (0.64%) were in the world’s top 1% of the most cited publications. The UK produced 665,467 (22.3%) of these publications and had over two and a half times more top 1% most cited publications than the EU+ (odds ratio 2.79, 95% CI 2.71–2.88, p ...
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