Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates
Around 85% of the environments on Earth are permanently or seasonally colder than 5 °C. Among those, the poles constitute unique biomes, which harbor a broad variety of microbial life, including an abundance of fungi. Many fungi have an outstanding ability to withstand extreme conditions and play vi...
Published in: | Microorganisms |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2019
|
Subjects: | |
Online Access: | https://zenodo.org/record/3556168 https://doi.org/10.3390/microorganisms7120600 |
id |
ftzenodo:oai:zenodo.org:3556168 |
---|---|
record_format |
openpolar |
spelling |
ftzenodo:oai:zenodo.org:3556168 2023-06-06T11:50:11+02:00 Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates Perini, Laura Mogrovejo, Diana C. Tomazin, Rok Gostinčar , Cene Brill, Florian H. H. Gunde-Cimerman, Nina 2019-11-22 https://zenodo.org/record/3556168 https://doi.org/10.3390/microorganisms7120600 eng eng info:eu-repo/grantAgreement/EC/H2020/675546/ https://zenodo.org/communities/microarctic https://zenodo.org/record/3556168 https://doi.org/10.3390/microorganisms7120600 oai:zenodo.org:3556168 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode Arctic fungi emerging pathogens thermotolerance hemolysis antifungal resistance info:eu-repo/semantics/article publication-article 2019 ftzenodo https://doi.org/10.3390/microorganisms7120600 2023-04-13T23:15:43Z Around 85% of the environments on Earth are permanently or seasonally colder than 5 °C. Among those, the poles constitute unique biomes, which harbor a broad variety of microbial life, including an abundance of fungi. Many fungi have an outstanding ability to withstand extreme conditions and play vital ecosystem roles of decomposers as well as obligate or facultative symbionts of many other organisms. Due to their dispersal capabilities, microorganisms from cryosphere samples can be distributed around the world. Such dispersal involves both species with undefined pathogenicity and potentially pathogenic strains. Here we describe the isolation of fungal species from pristine Arctic locations in Greenland and Svalbard and the testing of the expression of characteristics usually associated with pathogenic species, such as growth at 37 °C, hemolytic ability, and susceptibility to antifungal agents. A total of 320 fungal isolates were obtained, and 24 of the most abundant and representative species were further analyzed. Species known as emerging pathogens, like Aureobasidium melanogenum, Naganishia albida, and Rhodotorula mucilaginosa, were able to grow at 37 °C, showed beta-hemolytic activity, and were intrinsically resistant to commonly used antifungals such as azoles and echinocandins. Antifungal resistance screening revealed a low susceptibility to voriconazole in N. albida and Penicillium spp. and to fluconazole in Glaciozyma watsonii and Glaciozyma-related taxon. Article in Journal/Newspaper Arctic Greenland Svalbard Zenodo Arctic Greenland Svalbard Microorganisms 7 12 600 |
institution |
Open Polar |
collection |
Zenodo |
op_collection_id |
ftzenodo |
language |
English |
topic |
Arctic fungi emerging pathogens thermotolerance hemolysis antifungal resistance |
spellingShingle |
Arctic fungi emerging pathogens thermotolerance hemolysis antifungal resistance Perini, Laura Mogrovejo, Diana C. Tomazin, Rok Gostinčar , Cene Brill, Florian H. H. Gunde-Cimerman, Nina Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates |
topic_facet |
Arctic fungi emerging pathogens thermotolerance hemolysis antifungal resistance |
description |
Around 85% of the environments on Earth are permanently or seasonally colder than 5 °C. Among those, the poles constitute unique biomes, which harbor a broad variety of microbial life, including an abundance of fungi. Many fungi have an outstanding ability to withstand extreme conditions and play vital ecosystem roles of decomposers as well as obligate or facultative symbionts of many other organisms. Due to their dispersal capabilities, microorganisms from cryosphere samples can be distributed around the world. Such dispersal involves both species with undefined pathogenicity and potentially pathogenic strains. Here we describe the isolation of fungal species from pristine Arctic locations in Greenland and Svalbard and the testing of the expression of characteristics usually associated with pathogenic species, such as growth at 37 °C, hemolytic ability, and susceptibility to antifungal agents. A total of 320 fungal isolates were obtained, and 24 of the most abundant and representative species were further analyzed. Species known as emerging pathogens, like Aureobasidium melanogenum, Naganishia albida, and Rhodotorula mucilaginosa, were able to grow at 37 °C, showed beta-hemolytic activity, and were intrinsically resistant to commonly used antifungals such as azoles and echinocandins. Antifungal resistance screening revealed a low susceptibility to voriconazole in N. albida and Penicillium spp. and to fluconazole in Glaciozyma watsonii and Glaciozyma-related taxon. |
format |
Article in Journal/Newspaper |
author |
Perini, Laura Mogrovejo, Diana C. Tomazin, Rok Gostinčar , Cene Brill, Florian H. H. Gunde-Cimerman, Nina |
author_facet |
Perini, Laura Mogrovejo, Diana C. Tomazin, Rok Gostinčar , Cene Brill, Florian H. H. Gunde-Cimerman, Nina |
author_sort |
Perini, Laura |
title |
Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates |
title_short |
Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates |
title_full |
Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates |
title_fullStr |
Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates |
title_full_unstemmed |
Phenotypes Associated with Pathogenicity: Their Expression in Arctic Fungal Isolates |
title_sort |
phenotypes associated with pathogenicity: their expression in arctic fungal isolates |
publishDate |
2019 |
url |
https://zenodo.org/record/3556168 https://doi.org/10.3390/microorganisms7120600 |
geographic |
Arctic Greenland Svalbard |
geographic_facet |
Arctic Greenland Svalbard |
genre |
Arctic Greenland Svalbard |
genre_facet |
Arctic Greenland Svalbard |
op_relation |
info:eu-repo/grantAgreement/EC/H2020/675546/ https://zenodo.org/communities/microarctic https://zenodo.org/record/3556168 https://doi.org/10.3390/microorganisms7120600 oai:zenodo.org:3556168 |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode |
op_doi |
https://doi.org/10.3390/microorganisms7120600 |
container_title |
Microorganisms |
container_volume |
7 |
container_issue |
12 |
container_start_page |
600 |
_version_ |
1767955964729753600 |