Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study
Background: Evidence suggests a largely environmental component to non-Hodgkin's lymphoma (NHL). Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), DDE and HCB have been repeatedly implicated, but the literature is inconsistent and a causal relationship remains to...
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Online Access: | https://zenodo.org/record/344162 https://doi.org/10.1186/s12940-017-0214-8 |
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ftzenodo:oai:zenodo.org:344162 2023-05-15T17:45:07+02:00 Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study Kelly, Rachel S. Kiviranta, Hannu Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc on behalf of the EnviroGenoMarkers project consortium 2017-02-16 https://zenodo.org/record/344162 https://doi.org/10.1186/s12940-017-0214-8 unknown info:eu-repo/grantAgreement/EC/FP7/226756/ https://zenodo.org/communities/fp7-bmc https://zenodo.org/record/344162 https://doi.org/10.1186/s12940-017-0214-8 oai:zenodo.org:344162 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode Environmental Health 16(1) 9 Non Hodgkin lymphoma Polychlorinated biphenyls DDE HCB Organochlorines EnviroGenoMarkers info:eu-repo/semantics/article publication-article 2017 ftzenodo https://doi.org/10.1186/s12940-017-0214-8 2023-03-10T23:46:10Z Background: Evidence suggests a largely environmental component to non-Hodgkin's lymphoma (NHL). Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), DDE and HCB have been repeatedly implicated, but the literature is inconsistent and a causal relationship remains to be determined.Methods: The EnviroGenoMarkers study is nested within two prospective cohorts EPIC-Italy and the Northern Sweden Health and Disease Study. Six PCB congeners, DDE and HCB were measured in blood plasma samples provided at recruitment using gas-chromatography mass spectrometry. During 16 years follow-up 270 incident cases of B-cell NHL (including 76 cases of multiple myeloma) were diagnosed. Cases were matched to 270 healthy controls by centre, age, gender and date of blood collection. Cases were categorised into ordered quartiles of exposure for each POP based on the distribution of exposure in the control population. Logistic regression was applied to assess the association with risk, multivariate and stratified analyses were performed to identify confounders or effect modifiers.Results: The exposures displayed a strong degree of correlation, particularly amongst those PCBs with similar degrees of chlorination. There was no significant difference (p < 0.05) in median exposure levels between cases and controls for any of the investigated exposures. However under a multivariate model PCB138, PCB153, HCB and DDE displayed significant inverse trends (Wald test p-value <0.05). Under stratified analyses these were determined to be driven by males and by the Diffuse Large B-Cell Lymphoma subtype. When considering those in the highest levels of exposure (>90th percentile) the association was null for all POPsConclusion: We report no evidence that a higher body burden of PCBs, DDE or HCB increased the risk of subsequent NHL diagnosis. Significantly inverse associations were noted for males with a number of the investigated POPs. We hypothesize these unexpected relationships may relate to the subtype ... Article in Journal/Newspaper Northern Sweden Zenodo Environmental Health 16 1 |
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Zenodo |
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ftzenodo |
language |
unknown |
topic |
Non Hodgkin lymphoma Polychlorinated biphenyls DDE HCB Organochlorines EnviroGenoMarkers |
spellingShingle |
Non Hodgkin lymphoma Polychlorinated biphenyls DDE HCB Organochlorines EnviroGenoMarkers Kelly, Rachel S. Kiviranta, Hannu Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc on behalf of the EnviroGenoMarkers project consortium Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
topic_facet |
Non Hodgkin lymphoma Polychlorinated biphenyls DDE HCB Organochlorines EnviroGenoMarkers |
description |
Background: Evidence suggests a largely environmental component to non-Hodgkin's lymphoma (NHL). Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), DDE and HCB have been repeatedly implicated, but the literature is inconsistent and a causal relationship remains to be determined.Methods: The EnviroGenoMarkers study is nested within two prospective cohorts EPIC-Italy and the Northern Sweden Health and Disease Study. Six PCB congeners, DDE and HCB were measured in blood plasma samples provided at recruitment using gas-chromatography mass spectrometry. During 16 years follow-up 270 incident cases of B-cell NHL (including 76 cases of multiple myeloma) were diagnosed. Cases were matched to 270 healthy controls by centre, age, gender and date of blood collection. Cases were categorised into ordered quartiles of exposure for each POP based on the distribution of exposure in the control population. Logistic regression was applied to assess the association with risk, multivariate and stratified analyses were performed to identify confounders or effect modifiers.Results: The exposures displayed a strong degree of correlation, particularly amongst those PCBs with similar degrees of chlorination. There was no significant difference (p < 0.05) in median exposure levels between cases and controls for any of the investigated exposures. However under a multivariate model PCB138, PCB153, HCB and DDE displayed significant inverse trends (Wald test p-value <0.05). Under stratified analyses these were determined to be driven by males and by the Diffuse Large B-Cell Lymphoma subtype. When considering those in the highest levels of exposure (>90th percentile) the association was null for all POPsConclusion: We report no evidence that a higher body burden of PCBs, DDE or HCB increased the risk of subsequent NHL diagnosis. Significantly inverse associations were noted for males with a number of the investigated POPs. We hypothesize these unexpected relationships may relate to the subtype ... |
format |
Article in Journal/Newspaper |
author |
Kelly, Rachel S. Kiviranta, Hannu Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc on behalf of the EnviroGenoMarkers project consortium |
author_facet |
Kelly, Rachel S. Kiviranta, Hannu Bergdahl, Ingvar A. Palli, Domenico Johansson, Ann-Sofie Botsivali, Maria Vineis, Paolo Vermeulen, Roel Kyrtopoulos, Soterios A. Chadeau-Hyam, Marc on behalf of the EnviroGenoMarkers project consortium |
author_sort |
Kelly, Rachel S. |
title |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_short |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_full |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_fullStr |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_full_unstemmed |
Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study |
title_sort |
prediagnostic plasma concentrations of organochlorines and risk of b-cell non-hodgkin lymphoma in envirogenomarkers: a nested case-control study |
publishDate |
2017 |
url |
https://zenodo.org/record/344162 https://doi.org/10.1186/s12940-017-0214-8 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Environmental Health 16(1) 9 |
op_relation |
info:eu-repo/grantAgreement/EC/FP7/226756/ https://zenodo.org/communities/fp7-bmc https://zenodo.org/record/344162 https://doi.org/10.1186/s12940-017-0214-8 oai:zenodo.org:344162 |
op_rights |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/legalcode |
op_doi |
https://doi.org/10.1186/s12940-017-0214-8 |
container_title |
Environmental Health |
container_volume |
16 |
container_issue |
1 |
_version_ |
1766147885179600896 |