DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876....

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Published in:RESEARCH RESULT Pharmacology and Clinical Pharmacology
Main Authors: Buzov, Andrey, Kulikov, Alexandr, Avtina, Tatyana, Pokrovskii, Mikhail, Osipova, Ol'ga
Format: Article in Journal/Newspaper
Language:unknown
Published: Pensoft Publishers 2016
Subjects:
antidiabetic agent
С7070
the blood plasma of rats
high-performance liquid chromatography
mass spectrometric detection
validation
Carbonic acid
Online Access:https://doi.org/10.18413/2313-8971-2016-2-1-52-57
id ftzenodo:oai:zenodo.org:2534742
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spelling ftzenodo:oai:zenodo.org:2534742 2024-09-15T18:01:37+00:00 DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION Buzov, Andrey Kulikov, Alexandr Avtina, Tatyana Pokrovskii, Mikhail Osipova, Ol'ga 2016-03-30 https://doi.org/10.18413/2313-8971-2016-2-1-52-57 unknown Pensoft Publishers https://doi.org/10.18413/2313-8971-2016-2-1-52-57 oai:zenodo.org:2534742 info:eu-repo/semantics/openAccess Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode Research Results in Pharmacology, 2((1)), 52-57, (2016-03-30) antidiabetic agent С7070 the blood plasma of rats high-performance liquid chromatography mass spectrometric detection validation info:eu-repo/semantics/article 2016 ftzenodo https://doi.org/10.18413/2313-8971-2016-2-1-52-57 2024-07-26T05:22:51Z We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4. Article in Journal/Newspaper Carbonic acid Zenodo RESEARCH RESULT Pharmacology and Clinical Pharmacology 2 1
institution Open Polar
collection Zenodo
op_collection_id ftzenodo
language unknown
topic antidiabetic agent
С7070
the blood plasma of rats
high-performance liquid chromatography
mass spectrometric detection
validation
spellingShingle antidiabetic agent
С7070
the blood plasma of rats
high-performance liquid chromatography
mass spectrometric detection
validation
Buzov, Andrey
Kulikov, Alexandr
Avtina, Tatyana
Pokrovskii, Mikhail
Osipova, Ol'ga
DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
topic_facet antidiabetic agent
С7070
the blood plasma of rats
high-performance liquid chromatography
mass spectrometric detection
validation
description We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4.
format Article in Journal/Newspaper
author Buzov, Andrey
Kulikov, Alexandr
Avtina, Tatyana
Pokrovskii, Mikhail
Osipova, Ol'ga
author_facet Buzov, Andrey
Kulikov, Alexandr
Avtina, Tatyana
Pokrovskii, Mikhail
Osipova, Ol'ga
author_sort Buzov, Andrey
title DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_short DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_full DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_fullStr DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_full_unstemmed DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_sort development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection
publisher Pensoft Publishers
publishDate 2016
url https://doi.org/10.18413/2313-8971-2016-2-1-52-57
genre Carbonic acid
genre_facet Carbonic acid
op_source Research Results in Pharmacology, 2((1)), 52-57, (2016-03-30)
op_relation https://doi.org/10.18413/2313-8971-2016-2-1-52-57
oai:zenodo.org:2534742
op_rights info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
op_doi https://doi.org/10.18413/2313-8971-2016-2-1-52-57
container_title RESEARCH RESULT Pharmacology and Clinical Pharmacology
container_volume 2
container_issue 1
_version_ 1810438728989016064

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